caa a22 4500 445796723 CHVBK 20180317145128.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10620-010-1454-4 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1454-4 Obese Patients Have Stronger Peristalsis and Increased Acid Exposure in the Esophagus [Elektronische Daten] [Fernando Fornari, Sidia Callegari-Jacques, Roberto Dantas, Ana Scarsi, Liana Ruas, Sérgio de Barros] Background: Obesity is a risk factor for GERD and a potential modulator of esophageal motility. Aim: To assess whether obese patients differ from non-obese patients in terms of esophageal motility and reflux. Methods: Patients (n=332) were categorized in GERD and controls after clinical assessment, esophageal manometry, and pH monitoring. Non-obese (BMI 16-29.9) and obese (BMI 30-68) were compared in regard of distal esophageal amplitude (DEA), LES pressure (LESP), manometric diagnosis, and esophageal acid exposure (EAE). Results: Obese showed higher DEA in both controls (122±53 vs. 97±36mmHg, p=0.041) and GERD patients (109±38 vs. 94±46mmHg, p<0.001), higher LESP in GERD patients (20.5±10.6 vs. 18.2±10.6mmHg, p=0.049), higher frequency of nutcracker esophagus in controls (30 vs. 0%, p=0.001), lower frequency of ineffective motility in GERD patients (6 vs. 20%, p=0.001), and higher EAE in both controls [total EAE: 1.6% (0.7-5.1) vs. 0.9% (0.2-2.4), p=0.027] and GERD patients [upright EAE: 6.5% (3.8-11.1) vs. 5.2% (1.5-10.6), p=0.048]. Multiple linear regression showed that BMI was associated either with EAE (p<0.001), DEA (p=0.006), or LESP (in men, p=0.007). Conclusions: Obese patients differed from non-obese in terms of esophageal motility and reflux, regardless of the presence of GERD. Obese patients showed stronger peristalsis and increased acid exposure in the esophagus. Springer Science+Business Media, LLC, 2010 Body mass index nationallicence Esophageal motility disorders nationallicence Gastroesophageal reflux disease nationallicence Obesity nationallicence Fornari Fernando Faculdade de Medicina, Universidade de Passo Fundo, Rua Teixeira Soares, 817, 99010-080, Passo Fundo-RS, Brazil aut Callegari-Jacques Sidia Departamento de Estatística e Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre-RS, Brazil aut Dantas Roberto Departamento de Medicina, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP, Brazil aut Scarsi Ana Faculdade de Medicina, Universidade de Passo Fundo, Rua Teixeira Soares, 817, 99010-080, Passo Fundo-RS, Brazil aut Ruas Liana Faculdade de Medicina, Universidade de Passo Fundo, Rua Teixeira Soares, 817, 99010-080, Passo Fundo-RS, Brazil aut de Barros Sérgio Programa de Pós-Graduação: Ciências em Gastroenterologia, Faculdade de Medicina, UFRGS, Porto Alegre-RS, Brazil aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1420-1426 0163-2116 56:5<1420 2011 56 10620 https://doi.org/10.1007/s10620-010-1454-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1454-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fornari Fernando Faculdade de Medicina, Universidade de Passo Fundo, Rua Teixeira Soares, 817, 99010-080, Passo Fundo-RS, Brazil aut NATIONALLICENCE 700 1- Callegari-Jacques Sidia Departamento de Estatística e Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre-RS, Brazil aut NATIONALLICENCE 700 1- Dantas Roberto Departamento de Medicina, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP, Brazil aut NATIONALLICENCE 700 1- Scarsi Ana Faculdade de Medicina, Universidade de Passo Fundo, Rua Teixeira Soares, 817, 99010-080, Passo Fundo-RS, Brazil aut NATIONALLICENCE 700 1- Ruas Liana Faculdade de Medicina, Universidade de Passo Fundo, Rua Teixeira Soares, 817, 99010-080, Passo Fundo-RS, Brazil aut NATIONALLICENCE 700 1- de Barros Sérgio Programa de Pós-Graduação: Ciências em Gastroenterologia, Faculdade de Medicina, UFRGS, Porto Alegre-RS, Brazil aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1420-1426 0163-2116 56:5<1420 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer