caa a22 4500 445796774 CHVBK 20180317145128.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10620-010-1468-y doi (NATIONALLICENCE)springer-10.1007/s10620-010-1468-y Prospective Diary Evaluation of Unexplained Abdominal Pain and Bowel Dysfunction: A Population-Based Colonoscopy Study [Elektronische Daten] [Susanna Walter, Lars Kjellström, Nicholas Talley, Anna Andreasson, Henry Nyhlin, Lars Agréus] Introduction: Diagnostic criteria for irritable bowel syndrome (IBS) have not been validated by prospective symptom diary. We investigated the bowel patterns in community subjects with and without non-organic abdominal pain, and compared the symptoms with subjects fulfilling the Rome II criteria (IBS). Methods: From the Swedish population register, a random sample completed an abdominal symptom questionnaire. Responders were subsequently invited for a clinical evaluation and offered a colonoscopy regardless of whether they had abdominal symptoms or not. A total of 268 subjects underwent colonoscopy, clinical evaluation by gastroenterologist, laboratory investigations, and completed the Rome questionnaire and prospective gastrointestinal (GI) symptom diaries for 1week. Twenty-three subjects of 268 were excluded due to organic GI disease. Results: Subjects recorded 2,194 bowel movements and 370 abdominal pain episodes on 1,504days. Subjects with pain in the diary (n=81) had higher stool frequency (P=0.01), more urgency (P=0.0002), feelings of incomplete evacuation (P=0.0002), nausea (P=0.0009), and abdominal bloating (P=0.0005) than subjects without pain (n=151). Twenty-eight subjects (12%) fulfilled the Rome II criteria for IBS. Together, they had 96 pain episodes but only 4% were improved by defecation; 29% of the pain episodes started or worsened after a meal. Subjects with IBS and other subjects with non-organic abdominal pain (n=64) exhibited no differences in terms of the proportions of pain episodes improved by defecation, bloating, stool frequency, consistency, or defecatory symptoms. Conclusions: Current criteria for IBS that rely on recall of the relationship between abdominal pain and bowel disturbance may overcall this association when measured prospectively. Springer Science+Business Media, LLC, 2010 IBS nationallicence Irritable bowel syndrome nationallicence Gastrointestinal symptoms nationallicence Colonoscopy nationallicence Population nationallicence Prospective nationallicence Symptom diary nationallicence Functional bowel disorder nationallicence Rome nationallicence Abdominal pain nationallicence Functional nationallicence Walter Susanna Institution of Clinical and Experimental Medicine (IKE), Division of Gastroenterology, Linköping University, Linköping, Sweden aut Kjellström Lars Department of Gastroenterology, Sabbatsbergs Hospital, Karolinska Institutet, Stockholm, Sweden aut Talley Nicholas Faculty of Health, University of Newcastle, Newcastle, NSW, Australia aut Andreasson Anna Center for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden aut Nyhlin Henry Department of Gastroenterology, Karolinska Institutet, Stockholm, Sweden aut Agréus Lars Center for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1444-1451 0163-2116 56:5<1444 2011 56 10620 https://doi.org/10.1007/s10620-010-1468-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1468-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Walter Susanna Institution of Clinical and Experimental Medicine (IKE), Division of Gastroenterology, Linköping University, Linköping, Sweden aut NATIONALLICENCE 700 1- Kjellström Lars Department of Gastroenterology, Sabbatsbergs Hospital, Karolinska Institutet, Stockholm, Sweden aut NATIONALLICENCE 700 1- Talley Nicholas Faculty of Health, University of Newcastle, Newcastle, NSW, Australia aut NATIONALLICENCE 700 1- Andreasson Anna Center for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden aut NATIONALLICENCE 700 1- Nyhlin Henry Department of Gastroenterology, Karolinska Institutet, Stockholm, Sweden aut NATIONALLICENCE 700 1- Agréus Lars Center for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1444-1451 0163-2116 56:5<1444 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer