caa a22 4500 445796820 CHVBK 20180317145128.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10620-010-1514-9 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1514-9 Neural Autoantibody Evaluation in Functional Gastrointestinal Disorders: A Population-Based Case-Control Study [Elektronische Daten] [Sean Pittock, Vanda Lennon, Carissa Dege, Nicholas Talley, G. Locke III] Background: Our goal is to investigate the serum profile of neural autoantibodies in community-based patients with irritable bowel syndrome (IBS) or functional dyspepsia. The pathogenesis of functional gastrointestinal (GI) disorders, including IBS and dyspepsia, are unknown. Theories range from purely psychological to autoimmune alterations in GI tract neuromuscular function. Methods: The study subjects, based in Olmsted County, MN, reported symptoms of functional dyspepsia or IBS (n=69), or were asymptomatic controls (n=64). Their coded sera were screened for antibodies targeting neuronal, glial, and muscle autoantigens. Results: The prevalence of neural autoantibodies with functional GI disorders did not differ significantly from controls (17% vs. 13%; P=0.43). In no case was a neuronal or glial nuclear autoantibody or enteric neuronal autoantibody identified. Neuronal cation channel antibodies were identified in 9% of cases (voltage-gated potassium channel [VGKC] in one dyspepsia case and one IBS case, ganglionic acetylcholine receptor [AChR] in four IBS cases) and in 6% of controls (ganglionic AChR in one, voltage-gated calcium channel [VGCC], N-type, in two and VGKC in one; P=0.36). The frequency of glutamic acid decarboxylase-65 (GAD65) autoantibodies was similar in cases (10%) and controls (5%; P=0.23). Conclusions: Our data do not support neural autoimmunity as the basis for most IBS or functional dyspepsia cases. Springer Science+Business Media, LLC, 2010 Dyspepsia nationallicence Epidemiology nationallicence Irritable bowel syndrome nationallicence Autoimmune nationallicence Paraneoplastic nationallicence Pittock Sean Division of Multiple Sclerosis and Autoimmune Neurology, Department of Neurology, Mayo Clinic, 200 First Street S.W., 55905, Rochester, MN, USA aut Lennon Vanda Division of Multiple Sclerosis and Autoimmune Neurology, Department of Neurology, Mayo Clinic, 200 First Street S.W., 55905, Rochester, MN, USA aut Dege Carissa Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA aut Talley Nicholas Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research, Department of Medicine, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street S.W., 55905, Rochester, MN, USA aut Locke III G. Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research, Department of Medicine, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street S.W., 55905, Rochester, MN, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1452-1459 0163-2116 56:5<1452 2011 56 10620 https://doi.org/10.1007/s10620-010-1514-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1514-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pittock Sean Division of Multiple Sclerosis and Autoimmune Neurology, Department of Neurology, Mayo Clinic, 200 First Street S.W., 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Lennon Vanda Division of Multiple Sclerosis and Autoimmune Neurology, Department of Neurology, Mayo Clinic, 200 First Street S.W., 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Dege Carissa Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Talley Nicholas Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research, Department of Medicine, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street S.W., 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Locke III G. Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research, Department of Medicine, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street S.W., 55905, Rochester, MN, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1452-1459 0163-2116 56:5<1452 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer