caa a22 4500 445796898 CHVBK 20180317145128.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10620-010-1478-9 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1478-9 IgG4-Associated Cholecystitis: Another Clue in the Diagnosis of Autoimmune Pancreatitis [Elektronische Daten] [Michael Leise, Thomas Smyrk, Naoki Takahashi, Seth Sweetser, Santhi Vege, Suresh Chari] Purpose: Autoimmune pancreatitis (AIP) is the pancreatic manifestation of IgG4-associated systemic disease (ISD). Criteria for diagnosis of AIP include recognition of extra-pancreatic organ involvement. Because the diagnosis of AIP can be challenging, even for experts, it is important for clinicians to recognize other target organ damage in this disease. Typical gallbladder findings in AIP have been increasingly recognized. Because cholecystectomy is common in the community, the availability of previous tissue from the gallbladder can provide an important supportive clue in the diagnosis of AIP. The objective of this review is to examine the literature on common gallbladder pathology findings in AIP, and discuss their clinical utility. Results: Gallbladder involvement in AIP seems to be common. Transmural lymphoplasmacytic inflammatory infiltrates, extramural inflammatory nodules, the presence of tissue eosinophilia, phlebitis, and increased tissue IgG4 are all seen more frequently in the gallbladders of patients with AIP. These findings are not 100% specific, because some can be seen in primary sclerosing cholangitis and pancreatic adenocarcinoma. Conclusion: Cholecystectomy for the purpose of diagnosing AIP is not recommended. However, if gallbladder specimens from a previous cholecystectomy are available, an expert review of gallbladder slides with IgG4 immunostaining may help to provide additional criteria for diagnosis of autoimmune pancreatitis. Springer Science+Business Media, LLC, 2010 Autoimmune pancreatitis nationallicence IgG4-associated systemic disease nationallicence IgG4 nationallicence Gallbladder nationallicence Leise Michael Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Gonda Building 9th Floor, 200 First Street SW, 55905, Rochester, MN, USA aut Smyrk Thomas Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut Takahashi Naoki Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut Sweetser Seth Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Gonda Building 9th Floor, 200 First Street SW, 55905, Rochester, MN, USA aut Vege Santhi Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Gonda Building 9th Floor, 200 First Street SW, 55905, Rochester, MN, USA aut Chari Suresh Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Gonda Building 9th Floor, 200 First Street SW, 55905, Rochester, MN, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1290-1294 0163-2116 56:5<1290 2011 56 10620 https://doi.org/10.1007/s10620-010-1478-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1478-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Leise Michael Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Gonda Building 9th Floor, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Smyrk Thomas Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Takahashi Naoki Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Sweetser Seth Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Gonda Building 9th Floor, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Vege Santhi Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Gonda Building 9th Floor, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Chari Suresh Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Gonda Building 9th Floor, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1290-1294 0163-2116 56:5<1290 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer