caa a22 4500 44579691X CHVBK 20180317145128.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10620-011-1655-5 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1655-5 Esophageal Motor Disorders in Adults with Eosinophilic Esophagitis [Elektronische Daten] [Fouad Moawad, Corinne Maydonovitch, Ganesh Veerappan, John Bassett, Jason Lake, Roy Wong] Background: An association between eosinophilic esophagitis (EoE) and esophageal motility disorders has been described in small studies. Aims: The aim of this study was to describe the prevalence of esophageal motor disorders in a large cohort of adults with EoE and examine whether an association exists between esophageal dysmotility and dysphagia. Methods: A retrospective review of esophageal manometry studies in adult EoE patients was performed. Tracings were reviewed for abnormalities including nutcracker esophagus and ineffective swallows, defined as low amplitude peristalsis (<30mmHg) or non-propagating contractions. Ineffective esophageal motility (IEM) was categorized as mild (30-40% ineffective swallows), moderate (50-60% ineffective swallows), and severe (≥70% ineffective swallows). Dysphagia was graded on a 0-3 scale for frequency and severity. Results: Seventy-five tracings from EoE patients were reviewed (85% male, mean age 41±12years). IEM was identified in 25 patients and categorized as mild (n=13), moderate (n=6), and severe (n=6). Nutcracker esophagus was found in three patients. There was no significant difference in eosinophil count among the motility groups: normal 46.5±3.1, mild IEM 56.9±36.9, moderate IEM 45.5±23.7, severe IEM 34.3±12.6 (P=0.157). Conclusions: In this cohort of EoE patients, the majority had normal esophageal motility studies, although a subset of these patients had some esophageal dysmotility. It is unlikely that esophageal dysmotility is a major contributing factor to dysphagia, although it is reasonable to consider esophageal manometry testing in EoE patients to identify potential abnormalities of the smooth muscle esophagus. Springer Science+Business Media, LLC, 2011 Eosinophilic esophagitis nationallicence Esophageal dysmotility nationallicence Esophageal motor disorders nationallicence Dysphagia nationallicence Moawad Fouad Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, N.W., 20307, Washington, DC, USA aut Maydonovitch Corinne Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, N.W., 20307, Washington, DC, USA aut Veerappan Ganesh Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, N.W., 20307, Washington, DC, USA aut Bassett John Gastroenterology Service, Department of Medicine, Naval Hospital, Jacksonville, FL, USA aut Lake Jason Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, N.W., 20307, Washington, DC, USA aut Wong Roy Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, N.W., 20307, Washington, DC, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1427-1431 0163-2116 56:5<1427 2011 56 10620 https://doi.org/10.1007/s10620-011-1655-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1655-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moawad Fouad Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, N.W., 20307, Washington, DC, USA aut NATIONALLICENCE 700 1- Maydonovitch Corinne Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, N.W., 20307, Washington, DC, USA aut NATIONALLICENCE 700 1- Veerappan Ganesh Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, N.W., 20307, Washington, DC, USA aut NATIONALLICENCE 700 1- Bassett John Gastroenterology Service, Department of Medicine, Naval Hospital, Jacksonville, FL, USA aut NATIONALLICENCE 700 1- Lake Jason Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, N.W., 20307, Washington, DC, USA aut NATIONALLICENCE 700 1- Wong Roy Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, 6900 Georgia Avenue, N.W., 20307, Washington, DC, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1427-1431 0163-2116 56:5<1427 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer