caa a22 4500 445796936 CHVBK 20180317145128.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10620-010-1473-1 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1473-1 Incidence of Esophageal Carcinoma Among Malays in North-Eastern Peninsular Malaysia: An Area with an Exceptionally Low Prevalence of Helicobacter pylori Infection [Elektronische Daten] [Yeong Lee, S. Raj, Sharifah Sharif, Rosemi Salleh, Mukarramah Ayub, David Graham] Background: Obesity, gastroesophageal reflux, and Barrett's esophagus have all been linked to esophageal adenocarcinoma. In addition, the decline in Helicobacter pylori (H. pylori) infection in affluent societies has also been suggested to be a major factor in the recent rise in the incidence of esophageal adenocarcinoma. If H. pylori infection has a protective role, populations with a naturally low prevalence of H. pylori infection such as the ethnic Malays of Northeastern Peninsular Malaysia should have high rates of esophageal adenocarcinoma. Aim: To test this hypothesis, we investigated the incidence of esophageal carcinoma among the ethnic Malays of the state of Kelantan in Northeastern Peninsular Malaysia. Methods: The pathology services in the state of Kelantan are provided by two main hospitals. The histopathological records of both hospitals were systematically examined to retrieve all cases of esophageal carcinoma diagnosed between 2004 and 2008. Incidence rates were determined based on the most recent population census. Results: The age-standardized incidence rates (per 100,000 population) of esophageal adenocarcinoma among Malay men and women were 0.75 and 0.69, respectively. The corresponding rates for squamous cell carcinoma of the esophagus were 0.66 and 1.34, respectively. Conclusions: The low rates of adenocarcinoma and squamous cell carcinoma of the esophagus in the study area, despite the fact that H. pylori infection is virtually absent, does not support the hypothesis that the absence of H. pylori infection is a pivotal factor in the pathogenesis of these cancers. Springer Science+Business Media, LLC, 2010 Esophageal cancer nationallicence Helicobacter pylori nationallicence Malaysia nationallicence Incidence nationallicence Lee Yeong Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia aut Raj S. Department of Medicine, Pantai Hospital Kuala Lumpur, 59100, Kuala Lumpur, Malaysia aut Sharif Sharifah Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia aut Salleh Rosemi Department of Medicine, Hospital Raja Perempuan Zainab II, 15586, Kota Bahru, Kelantan, Malaysia aut Ayub Mukarramah Department of Pathology; Hospital Raja Perempuan Zainab II, 15586, Kota Bahru, Kelantan, Malaysia aut Graham David Michael E. DeBakey Veteran Affairs Medical Center and Baylor College of Medicine, 77030, Houston, Texas, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1438-1443 0163-2116 56:5<1438 2011 56 10620 https://doi.org/10.1007/s10620-010-1473-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1473-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Yeong Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia aut NATIONALLICENCE 700 1- Raj S. Department of Medicine, Pantai Hospital Kuala Lumpur, 59100, Kuala Lumpur, Malaysia aut NATIONALLICENCE 700 1- Sharif Sharifah Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia aut NATIONALLICENCE 700 1- Salleh Rosemi Department of Medicine, Hospital Raja Perempuan Zainab II, 15586, Kota Bahru, Kelantan, Malaysia aut NATIONALLICENCE 700 1- Ayub Mukarramah Department of Pathology; Hospital Raja Perempuan Zainab II, 15586, Kota Bahru, Kelantan, Malaysia aut NATIONALLICENCE 700 1- Graham David Michael E. DeBakey Veteran Affairs Medical Center and Baylor College of Medicine, 77030, Houston, Texas, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1438-1443 0163-2116 56:5<1438 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer