caa a22 4500 445796952 CHVBK 20180317145128.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10620-010-1430-z doi (NATIONALLICENCE)springer-10.1007/s10620-010-1430-z Incidence and Risk Factors for Lymphoma in a Single-Center Inflammatory Bowel Disease Population [Elektronische Daten] [Michael Chiorean, Bhupesh Pokhrel, Jaya Adabala, Debra Helper, Cynthia Johnson, Beth Juliar] Aims: Previous studies on the risk of lymphoma in inflammatory bowel disease (IBD) have yielded conflicting results. We aim to determine the incidence and risk factors for lymphoma in a large IBD population. Methods: Patients with lymphoma were identified from a single-center IBD database. The standardized incidence ratio (SIR) of lymphoma was estimated using data from the Surveillance, Epidemiology and End Results (SEER) registry. Risk factors for lymphoma were determined by comparing cases with a matched IBD control group. Results: Eleven lymphomas were identified among 3,585 IBD patients during an average of 8.4years of observation. Three patients were excluded. In the remaining eight, median age at diagnosis was 47years and mean IBD duration was 20years (range 7.5-45years). The SIR for lymphoma was 1.6 [95% confidence interval (CI) 0.6-3.0], and for non-Hodgkin lymphoma (NHL), 1.5 (0.3-2.8). Three lymphoma patients (38%) received prior immunomodulators and two (25%) received biologics, versus 57% and 39% in the control group, respectively (P=0.4). No correlation was seen with tobacco exposure, disease duration, use, or dose or duration of immunosuppressive therapy. Conclusions: In this IBD cohort, risk of lymphoma was not increased compared with the general population. Risk of lymphoma was not associated with any demographic or therapy-related factors. Springer Science+Business Media, LLC, 2010 Inflammatory bowel disease nationallicence Lymphoproliferative disease nationallicence IBD : Inflammatory bowel disease nationallicence NHL : Non-Hodgkin lymphoma nationallicence HL : Hodgkin lymphoma nationallicence IM : Immunomodulators nationallicence TNF-α : Tumor necrosis factor-α nationallicence Chiorean Michael Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 550 N University Blvd., Indianapolis, IN, USA aut Pokhrel Bhupesh Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA aut Adabala Jaya Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA aut Helper Debra Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 550 N University Blvd., Indianapolis, IN, USA aut Johnson Cynthia Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA aut Juliar Beth Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1489-1495 0163-2116 56:5<1489 2011 56 10620 https://doi.org/10.1007/s10620-010-1430-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1430-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chiorean Michael Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 550 N University Blvd., Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Pokhrel Bhupesh Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Adabala Jaya Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Helper Debra Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 550 N University Blvd., Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Johnson Cynthia Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Juliar Beth Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1489-1495 0163-2116 56:5<1489 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer