caa a22 4500 445797010 CHVBK 20180317145128.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10620-010-1429-5 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1429-5 Surgical Prophylaxis of Pouchitis in Ulcerative Colitis [Elektronische Daten] [Giuseppe Brisinda, Serafino Vanella, Venanzio Valenza, Anna Crocco, Germano Perotti, Daniela Di Giuda, Giorgio Maria] Ileal pouch-anal anastomosis (IPAA) is now the procedure of choice for most patients requiring proctocolectomy for ulcerative colitis. The J-shaped pouch, usually 15-20cm in length, is easiest to construct and has functional outcomes identical to those of the more complex designs. IPAA is a complex procedure, and complications occur frequently. Despite the significant improvements this surgical advance has made on the quality of life in these patients, inflammation of the surgically created ileal pouch or pouchitis remains a major late postoperative complication that can often overshadow the benefits of this otherwise curative operation. Several inflammatory and noninflammatory complications can occur after IPAA. Pouchitis is the most common, occurring in ≈50% of patients. Whereas acute pouchitis can be treated rapidly and successfully in the majority of patients, refractory and chronic pouchitis remain therapeutic challenges to patients and physicians. The problem is believed to be caused by stasis of feces in the pouch with overgrowth of aerobic and anaerobic organisms. The size of the pouch has a significant influence on the incidence of pouchitis: a smaller pouch usually empties better than a larger pouch and so may be less susceptible to pouchitis. Springer Science+Business Media, LLC, 2010 Acute pouchitis nationallicence Chronic pouchitis nationallicence Familial adenomatous polyposis nationallicence Ileal pouch nationallicence Ulcerative colitis nationallicence Surgery nationallicence Postoperative complications nationallicence Drug therapy nationallicence Physiopathology nationallicence Proctocolectomy nationallicence Brisinda Giuseppe Department of Surgery, Catholic University Hospital "Agostino Gemelli”, Largo Agostino Gemelli 8, 00168, Rome, Italy aut Vanella Serafino Department of Surgery, Catholic University Hospital "Agostino Gemelli”, Largo Agostino Gemelli 8, 00168, Rome, Italy aut Valenza Venanzio Institute of Nuclear Medicine, Catholic University Hospital "Agostino Gemelli”, 00168, Rome, Italy aut Crocco Anna Department of Surgery, Catholic University Hospital "Agostino Gemelli”, Largo Agostino Gemelli 8, 00168, Rome, Italy aut Perotti Germano Institute of Nuclear Medicine, Catholic University Hospital "Agostino Gemelli”, 00168, Rome, Italy aut Di Giuda Daniela Institute of Nuclear Medicine, Catholic University Hospital "Agostino Gemelli”, 00168, Rome, Italy aut Maria Giorgio Department of Surgery, Catholic University Hospital "Agostino Gemelli”, Largo Agostino Gemelli 8, 00168, Rome, Italy aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1257-1265 0163-2116 56:5<1257 2011 56 10620 https://doi.org/10.1007/s10620-010-1429-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1429-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brisinda Giuseppe Department of Surgery, Catholic University Hospital "Agostino Gemelli”, Largo Agostino Gemelli 8, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Vanella Serafino Department of Surgery, Catholic University Hospital "Agostino Gemelli”, Largo Agostino Gemelli 8, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Valenza Venanzio Institute of Nuclear Medicine, Catholic University Hospital "Agostino Gemelli”, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Crocco Anna Department of Surgery, Catholic University Hospital "Agostino Gemelli”, Largo Agostino Gemelli 8, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Perotti Germano Institute of Nuclear Medicine, Catholic University Hospital "Agostino Gemelli”, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Di Giuda Daniela Institute of Nuclear Medicine, Catholic University Hospital "Agostino Gemelli”, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Maria Giorgio Department of Surgery, Catholic University Hospital "Agostino Gemelli”, Largo Agostino Gemelli 8, 00168, Rome, Italy aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1257-1265 0163-2116 56:5<1257 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer