caa a22 4500 445797053 CHVBK 20180317145129.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10620-010-1460-6 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1460-6 Can Contrast-Enhanced Ultrasound Evaluate the Severity of Acute Pancreatitis? [Elektronische Daten] [Qiang Lu, Yue Zhong, Xiao-rong Wen, Zong-wen Huang, Yu-ting Fan, Qing Xia, Yan Luo] Objectives: To investigate the ability of contrast-enhanced ultrasound (CEUS) in the assessment of acute pancreatitis (AP), as well as its diagnostic accuracy in the evaluation of the severity of pancreatitis. Methods: A prospective double-blind study was carried out in 33 AP patients from May 2007 to January 2008. Each patient underwent both CEUS and contrast-enhanced computed tomography (CECT) with the time interval between two examinations less than 72h. Using CECT as gold standard, the ability of CEUS to diagnose pancreatic necrosis as well as peripancreatic effusion and/or complications, and its diagnostic value in the evaluation of the severity of pancreatitis, were investigated. Balthazar's grading system was used to measure CT and ultrasound severity indices (CTSI and USSI), and the correlation between CTSI and USSI was tested by Spearman's rank correlation coefficient. Results: A strong correlation between CTSI and USSI was found (r=0.92, P<0.01).The sensitivity, specificity, accuracy, positive and negative predictive value of CEUS in the diagnosis of pancreatic parenchyma necrosis were 90, 95, 94, 90 and 95%, in the diagnosis of peripancreatic effusion and/or complications were 83, 100, 93, 100 and 91%, and in the diagnosis of severe pancreatitis were 97, 67, 94, 97 and 67%, respectively. Conclusions: CEUS has shown to be of clinical value in the assessment of pancreatic necrosis as well as peripancreatic complications in AP and has a high diagnostic accuracy in the evaluation of the severity of pancreatitis. Further studies are needed to add it to the diagnostic algorithm for acute pancreatitis. Springer Science+Business Media, LLC, 2010 Contrast-enhanced ultrasound nationallicence Pancreatic necrosis nationallicence Acute pancreatitis nationallicence Contrast-enhanced computed tomography nationallicence Lu Qiang Department of Sonography, West China Hospital, Sichuan University, 610041, Chengdu, China aut Zhong Yue Department of Sonography, West China Hospital, Sichuan University, 610041, Chengdu, China aut Wen Xiao-rong Department of Sonography, West China Hospital, Sichuan University, 610041, Chengdu, China aut Huang Zong-wen Department of Western and Chinese Integrate Medicine, West China Hospital, Sichuan University, Chengdu, China aut Fan Yu-ting Department of Sonography, West China Hospital, Sichuan University, 610041, Chengdu, China aut Xia Qing Department of Western and Chinese Integrate Medicine, West China Hospital, Sichuan University, Chengdu, China aut Luo Yan Department of Sonography, West China Hospital, Sichuan University, 610041, Chengdu, China aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1578-1584 0163-2116 56:5<1578 2011 56 10620 https://doi.org/10.1007/s10620-010-1460-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1460-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lu Qiang Department of Sonography, West China Hospital, Sichuan University, 610041, Chengdu, China aut NATIONALLICENCE 700 1- Zhong Yue Department of Sonography, West China Hospital, Sichuan University, 610041, Chengdu, China aut NATIONALLICENCE 700 1- Wen Xiao-rong Department of Sonography, West China Hospital, Sichuan University, 610041, Chengdu, China aut NATIONALLICENCE 700 1- Huang Zong-wen Department of Western and Chinese Integrate Medicine, West China Hospital, Sichuan University, Chengdu, China aut NATIONALLICENCE 700 1- Fan Yu-ting Department of Sonography, West China Hospital, Sichuan University, 610041, Chengdu, China aut NATIONALLICENCE 700 1- Xia Qing Department of Western and Chinese Integrate Medicine, West China Hospital, Sichuan University, Chengdu, China aut NATIONALLICENCE 700 1- Luo Yan Department of Sonography, West China Hospital, Sichuan University, 610041, Chengdu, China aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/5(2011-05-01), 1578-1584 0163-2116 56:5<1578 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer