caa a22 4500 445797185 CHVBK 20180317145129.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10620-010-1305-3 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1305-3 Non-Invasive Index for Predicting Significant Liver Fibrosis: Comparison of Diagnostic Performances in Patients with Chronic Hepatitis B and C [Elektronische Daten] [Jae Cheong, Soon Um, Yeon Seo, Dong Kim, Seong Hwang, Youn Lee, Mong Cho, Jin Yang, Young Kim, Young Park, Sung Cho] Background/Aims: The majority of non-invasive markers of liver fibrosis have been developed in patients with chronic hepatitis C. We aimed to develop a formula for predicting significant fibrosis in patients with chronic viral hepatitis and to compare the usefulness of published models derived from the data obtained from patients with chronic hepatitis C. Methods: Serum markers and the METAVIR stage of fibrosis in liver biopsy specimens were compared prospectively in patients with chronic hepatitis B and C (estimation set, 367; validation set, 159). Results: In the estimation set, multiple forward stepwise logistic regression analysis identified γ-glutamyl transpeptidase, haptoglobin, α2-macroglobulin, matrix metalloproteinase-2, and tissue inhibitor of metalloproteinase-1 as independent predictors of significant fibrosis. A formula termed the SF index was constructed with the aforementioned five variables. The areas under the receiver operating characteristic curves of the SF index for predicting significant fibrosis were 0.828, 0.776, and 0.827 in the estimation, validation, and total sets, respectively. Using cut-off scores of 2.2 and 3.3, significant fibrosis was predicted with considerable accuracy. The diagnostic performances of the SF index and the Zeng index derived from chronic hepatitis B patients were much better than indices derived from chronic hepatitis C patients, such as the APRI, Forns index, and FIB-4. Conclusions: We developed a novel formula for predicting significant fibrosis in patients with chronic viral hepatitis. Serum indices from studies in patients with chronic hepatitis C were less accurate in patients with chronic hepatitis B for predicting significant fibrosis. Springer Science+Business Media, LLC, 2010 Chronic hepatitis nationallicence Liver fibrosis nationallicence Fibrosis marker nationallicence Cheong Jae Department of Gastroenterology, Ajou University School of Medicine, San-5 Wonchon-Dong, Youngtong-ku, 442-721, Suwon, South Korea aut Um Soon Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea aut Seo Yeon Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea aut Kim Dong Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea aut Hwang Seong Department of Internal Medicine, Pochon CHA University College of Medicine, Sungnam, South Korea aut Lee Youn Department of Internal Medicine, Inje University College of Medicine, Pusan, South Korea aut Cho Mong Department of Internal Medicine, Pusan National University College of Medicine, Pusan, South Korea aut Yang Jin Department of Internal Medicine, Catholic University College of Medicine, Suwon, South Korea aut Kim Young Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea aut Park Young Department of Pathology, Ajou University School of Medicine, Suwon, South Korea aut Cho Sung Department of Gastroenterology, Ajou University School of Medicine, San-5 Wonchon-Dong, Youngtong-ku, 442-721, Suwon, South Korea aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 555-563 0163-2116 56:2<555 2011 56 10620 https://doi.org/10.1007/s10620-010-1305-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1305-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cheong Jae Department of Gastroenterology, Ajou University School of Medicine, San-5 Wonchon-Dong, Youngtong-ku, 442-721, Suwon, South Korea aut NATIONALLICENCE 700 1- Um Soon Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Seo Yeon Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Dong Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea aut NATIONALLICENCE 700 1- Hwang Seong Department of Internal Medicine, Pochon CHA University College of Medicine, Sungnam, South Korea aut NATIONALLICENCE 700 1- Lee Youn Department of Internal Medicine, Inje University College of Medicine, Pusan, South Korea aut NATIONALLICENCE 700 1- Cho Mong Department of Internal Medicine, Pusan National University College of Medicine, Pusan, South Korea aut NATIONALLICENCE 700 1- Yang Jin Department of Internal Medicine, Catholic University College of Medicine, Suwon, South Korea aut NATIONALLICENCE 700 1- Kim Young Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Park Young Department of Pathology, Ajou University School of Medicine, Suwon, South Korea aut NATIONALLICENCE 700 1- Cho Sung Department of Gastroenterology, Ajou University School of Medicine, San-5 Wonchon-Dong, Youngtong-ku, 442-721, Suwon, South Korea aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 555-563 0163-2116 56:2<555 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer