caa a22 4500 445797266 CHVBK 20180317145129.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10620-010-1304-4 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1304-4 A Retrospective Study of the Safety and Efficacy of ERCP in Octogenarians [Elektronische Daten] [Massud Ali, Greg Ward, Doug Staley, Donald Duerksen] Background: Pancreatobiliary disease is increased in elderly patients. Because of significant comorbidities, these patients may be at greater risk of developing complications related to endoscopic retrograde cholangiopantreatography (ERCP). Objective: The purpose of this study was to compare the indications, interventions, and complications of ERCP of octogenarians with nonoctogenarians. Methods: A retrospective review of patient records from a single tertiary care hospital was performed. Adult patients undergoing ERCP were divided into two groups according to age. Group 1 patients were of age<80 years (N=391), and group 2 patients were>80 years of age (N=102). Indications, therapeutic interventions, use of conscious sedation, duration of procedure and complications were retrieved from the patient records. Main outcome measurements included: indications, therapeutic interventions, use of conscious sedation, duration of procedure and complications. Results: There was an increase in sphincterotomy rates (74 vs 63%; P<0.05) and stent insertions (48 vs 29%; P<0.001) in the octogenarian group. In group 1 there were 19 cases (4.9%) of post ERCP pancreatitis who spent 251 hospital days (including 59 ICU days) compared with one case (0.98%) in group 2 who required ten hospital days (P<0.05) and 0 ICU days. Procedure time for octogenarians was greater than nonoctogenarians (33.1 vs 29.8min; P<0.05). Octogenarians required less conscious sedation than nonoctogenarians (midazolam 4.1 vs 5.9mg; P<0.05 and fentanyl 45.5 vs 80.4mcg; P<0.05). Conclusions: In octogenarians, ERCP is efficacious and safe. It is associated with a lower rate of hospitalization for pancreatitis. ERCP in octogenarians takes longer, is associated with increased interventions (stent insertion and sphincterotomy) and requires less sedation. Springer Science+Business Media, LLC, 2010 ERCP nationallicence Elderly nationallicence Pancreatitis nationallicence Octogenarians nationallicence Ali Massud Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada aut Ward Greg Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada aut Staley Doug Office of Clinical Research, St. Boniface General Hospital, R2H 2A6, Winnipeg, MB, Canada aut Duerksen Donald Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 586-590 0163-2116 56:2<586 2011 56 10620 https://doi.org/10.1007/s10620-010-1304-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1304-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ali Massud Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Ward Greg Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Staley Doug Office of Clinical Research, St. Boniface General Hospital, R2H 2A6, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Duerksen Donald Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 586-590 0163-2116 56:2<586 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer