caa a22 4500 445797320 CHVBK 20180317145129.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10620-010-1307-1 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1307-1 Antioxidant Properties of Probiotics and Their Protective Effects in the Pathogenesis of Radiation-Induced Enteritis and Colitis [Elektronische Daten] [Basileios Spyropoulos, Evangelos Misiakos, Constantine Fotiadis, Christos Stoidis] Radiation therapy has become one of the most important treatment modalities for human malignancy, but certain immediate and delayed side-effects on the normal surrounding tissues limit the amount of effective radiation that can be administered. After exposure of the abdominal region to ionizing radiation, nearly all patients experience transient symptoms of irradiation of the bowel. Acute-phase symptoms may persist for a short time, yet long-term complications can represent significant clinical conditions with high morbidity. Data from both experimental studies and clinical trials suggest the potential benefit for probiotics in radiation-induced enteritis and colitis. On the other hand, it is well evidenced that both useful and harmful effects of therapeutic applications of ionizing radiation upon living systems are ascribed to free-radical production. Therefore, the hypothesis that probiotics reinforce antioxidant defense systems of normal mucosal cells exposed to ionizing radiation may explain to an extent their beneficial action. The aim of this review is threefold: First, to make a short brief into the natural history of radiation injury to the intestinal tract. Second, to describe the primary interaction of ionizing radiation at the cellular level and demonstrate the participation of free radicals in the mechanisms of injury and, third, to try a more profound investigation into the antioxidant abilities of probiotics and prebiotics based on the available experimental and clinical data. Springer Science+Business Media, LLC, 2010 Radiation enteritis nationallicence Radiation colitis nationallicence Oxidative stress nationallicence Probiotics nationallicence Prebiotics nationallicence Spyropoulos Basileios 1st Department of Propaedeutic Surgery, University of Athens School of Medicine, Hippokration Hospital, Athens, Greece aut Misiakos Evangelos 3rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, Rimini 1, 12462, Chaidari, Athens, Greece aut Fotiadis Constantine 3rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, Rimini 1, 12462, Chaidari, Athens, Greece aut Stoidis Christos 3rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, Rimini 1, 12462, Chaidari, Athens, Greece aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 285-294 0163-2116 56:2<285 2011 56 10620 https://doi.org/10.1007/s10620-010-1307-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1307-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Spyropoulos Basileios 1st Department of Propaedeutic Surgery, University of Athens School of Medicine, Hippokration Hospital, Athens, Greece aut NATIONALLICENCE 700 1- Misiakos Evangelos 3rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, Rimini 1, 12462, Chaidari, Athens, Greece aut NATIONALLICENCE 700 1- Fotiadis Constantine 3rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, Rimini 1, 12462, Chaidari, Athens, Greece aut NATIONALLICENCE 700 1- Stoidis Christos 3rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, Rimini 1, 12462, Chaidari, Athens, Greece aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 285-294 0163-2116 56:2<285 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer