caa a22 4500 445797347 CHVBK 20180317145130.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10620-010-1444-6 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1444-6 Development of Hepatocellular Carcinoma in Autoimmune Hepatitis Patients: A Case Series [Elektronische Daten] [Robert Wong, Robert Gish, Todd Frederick, Natalie Bzowej, Catherine Frenette] Background: The risk of hepatocellular carcinoma (HCC) among patients with autoimmune hepatitis (AIH) is believed to be low compared with other chronic liver diseases, and uncertainty exists over the need to perform HCC surveillance. If surveillance is initiated, the optimal timing is also not yet defined. Aims: The aim of the study was to investigate the prevalence of HCC among AIH patients. Methods: This was a retrospective study analyzing patient data from 1999 to 2009 in a large tertiary-care community hospital to assess the prevalence of HCC among AIH patients. Results: Among 322 AIH cases, cancer screening identified six patients that developed HCC (prevalence: 459 per 100,000 patient-years). All six patients were extracted from the subset of AIH patients with cirrhosis (n=50), resulting in a prevalence of 1,920 per 100,000 patient-years. In the AIH with HCC cohort, mean age of AIH diagnosis was 51.8years (range, 24-70) and mean age of HCC diagnosis was 60.0years (range, 37-71). The mean interval between diagnosis of AIH and HCC was 10.0years. Three patients had AJCC stage ≥2 cancer at diagnosis, and two had BCLC stage B or C. Conclusions: The risk of HCC among AIH patients with cirrhosis is 1.9% per year. This is comparable to HCC risk among patients with cirrhosis secondary to HBV, HCV, hemochromatosis, or alcohol-related liver disease. Although this data needs to be confirmed in prospective studies, routine cancer screening and surveillance among this cohort for early detection and treatment should be conducted. Springer Science+Business Media, LLC, 2010 Hepatocellular carcinoma screening nationallicence Liver cancer surveillance nationallicence Autoimmune hepatitis with cirrhosis nationallicence Autoimmune hepatitis epidemiology nationallicence Wong Robert Department of Medicine, California Pacific Medical Center, 2351 Clay Street, Suite 380, 94115, San Francisco, CA, USA aut Gish Robert Department of Liver Disease and Transplant Hepatology, California Pacific Medical Center, San Francisco, CA, USA aut Frederick Todd Department of Liver Disease and Transplant Hepatology, California Pacific Medical Center, San Francisco, CA, USA aut Bzowej Natalie Department of Liver Disease and Transplant Hepatology, California Pacific Medical Center, San Francisco, CA, USA aut Frenette Catherine Department of Liver Disease and Transplant Hepatology, California Pacific Medical Center, San Francisco, CA, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 578-585 0163-2116 56:2<578 2011 56 10620 https://doi.org/10.1007/s10620-010-1444-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1444-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wong Robert Department of Medicine, California Pacific Medical Center, 2351 Clay Street, Suite 380, 94115, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Gish Robert Department of Liver Disease and Transplant Hepatology, California Pacific Medical Center, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Frederick Todd Department of Liver Disease and Transplant Hepatology, California Pacific Medical Center, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Bzowej Natalie Department of Liver Disease and Transplant Hepatology, California Pacific Medical Center, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Frenette Catherine Department of Liver Disease and Transplant Hepatology, California Pacific Medical Center, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 578-585 0163-2116 56:2<578 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer