caa a22 4500 44579738X CHVBK 20180317145130.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10620-010-1295-1 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1295-1 A Short Primer on the Calcium Sensing Receptor: An Important Cog in the Colon Cancer Wheel? [Elektronische Daten] [Vishal Ghevariya, Sury Anand] The gastrointestinal (GI) tract handles a complex task of nutrient absorption and excretion of excess fluid, electrolytes, and toxic substances. GI epithelium is under constant proliferation and renewal. Differentiation of colonocytes occurs as they migrate from the basal layer to the apex of the crypt. Cells of the basal layer are highly proliferative but less differentiated, whereas apical cells are highly differentiated but non-proliferative. Alterations of this intricate process lead to abnormal proliferation and differentiation of colorectal mucosa leading to development of polyps and neoplasia. The effects of calcium (Ca) on colorectal mucosal growth have been extensively studied after the discovery of the calcium sensing receptor (CaSR). Fluctuation in extracellular Ca can induce hyperproliferation or quiescence. Disruption in the function of CaSR and/or changes in the level of CaSR expression can cause loss of growth suppressing effects of extracellular Ca. This review addresses the role of Ca and CaSR in the physiology and pathophysiology of colonocyte proliferation. Springer Science+Business Media, LLC, 2010 Colon cancer nationallicence Colonocytes nationallicence Calcium nationallicence Chemoprevention nationallicence GI : Gastrointestinal nationallicence Ca : Calcium nationallicence CaSR : Calcium sensing receptor nationallicence ATP : Adenosine triphosphate nationallicence GPCR : G-protein coupled receptor nationallicence MAPK : Mitogen-activated protein kinase nationallicence APC : Adenomatous polyposis coli nationallicence TA : Transit amplifying nationallicence DNA : Deoxyribonucleic acid nationallicence HMG : High mobility group nationallicence TCF : T-cell factor nationallicence PKC : Protein kinase nationallicence GSK : Glycogen synthase kinase nationallicence VDR : Vitamin D receptor nationallicence SC : Stem cell nationallicence NSC : Non-stem cell nationallicence SI : Sucrase isomaltase nationallicence Ghevariya Vishal Division of Gastroenterology, The Brooklyn Hospital Center, 240, Willoughby Street, 4 B, 11201, Brooklyn, NY, USA aut Anand Sury Division of Gastroenterology, The Brooklyn Hospital Center, 240, Willoughby Street, 4 B, 11201, Brooklyn, NY, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 279-284 0163-2116 56:2<279 2011 56 10620 https://doi.org/10.1007/s10620-010-1295-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1295-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ghevariya Vishal Division of Gastroenterology, The Brooklyn Hospital Center, 240, Willoughby Street, 4 B, 11201, Brooklyn, NY, USA aut NATIONALLICENCE 700 1- Anand Sury Division of Gastroenterology, The Brooklyn Hospital Center, 240, Willoughby Street, 4 B, 11201, Brooklyn, NY, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 279-284 0163-2116 56:2<279 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer