caa a22 4500 445797398 CHVBK 20180317145130.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10620-010-1382-3 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1382-3 Renin-Angiotensin System Associated with Risk of Upper GI Mucosal Injury Induced by Low Dose Aspirin [Elektronische Daten] Renin Angiotensin System Genes' Polymorphism [Akiko Shiotani, Ryuji Nishi, Yoshiyuki Yamanaka, Takahisa Murao, Hiroshi Matsumoto, Ken-ichi Tarumi, Tomoari Kamada, Takashi Sakakibara, Ken Haruma] Background: We have previously shown that co-treatment of angiotensin type 1 receptor (AT1R) blocker (ARB) or angiotensin converting enzyme (ACE) inhibitor seem to reduce peptic ulcer among patients taking low dose aspirin. It is reported that a series of renin-angiotensin system (RAS) gene polymorphisms significantly influence the rate of the gene transcription. Aim: The aim of this study was to examine the genotypes of RAS genes related to the risk of peptic ulcer and ulcer bleeding among patients taking low dose aspirin. Methods: Patients taking 100mg of aspirin who were planning to undergo endoscopy for surveillance or who had history of recent upper GI ulcer bleeding were included. ACE (Ins/Del), angiotensinogen (AGT; G-217A, A-20C, A-6G, T174M, M235T), and AT1R (T-713G, C-521T, A1166C) genotypes were determined by PCR or PCR-RFLP. Results: Four hundred twenty-five patients were enrolled including 68 patients with peptic ulcer and 20 patients with ulcer bleeding. Co-treatment of ARB was significantly associated with peptic ulcer and ulcer bleeding. AGT-20 CC (adjusted OR 4.94, 95% CI 1.21-20.2) was significantly associated with ulcer bleeding. The CC genotype of AT1R-521 was significantly associated with peptic ulcer only in the subgroup taking neither ACE inhibitor nor ARB. Conclusions: Co-treatment of ARB reduces peptic ulcer and bleeding among patients taking low dose aspirin. RAS may play an important role in the development of upper GI mucosal injury induced by low dose aspirin. Springer Science+Business Media, LLC, 2010 Angiotensin type 1 receptor blocker nationallicence Renin-angiotensin system nationallicence Angiotensinogen nationallicence Genotype nationallicence Shiotani Akiko Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut Nishi Ryuji Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut Yamanaka Yoshiyuki Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut Murao Takahisa Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut Matsumoto Hiroshi Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut Tarumi Ken-ichi Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut Kamada Tomoari Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut Sakakibara Takashi Department of Gastroenterology, Sakakibara Heart Institute of Okayama, Okayama, Japan aut Haruma Ken Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 465-471 0163-2116 56:2<465 2011 56 10620 https://doi.org/10.1007/s10620-010-1382-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1382-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shiotani Akiko Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut NATIONALLICENCE 700 1- Nishi Ryuji Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut NATIONALLICENCE 700 1- Yamanaka Yoshiyuki Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut NATIONALLICENCE 700 1- Murao Takahisa Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut NATIONALLICENCE 700 1- Matsumoto Hiroshi Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut NATIONALLICENCE 700 1- Tarumi Ken-ichi Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut NATIONALLICENCE 700 1- Kamada Tomoari Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut NATIONALLICENCE 700 1- Sakakibara Takashi Department of Gastroenterology, Sakakibara Heart Institute of Okayama, Okayama, Japan aut NATIONALLICENCE 700 1- Haruma Ken Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima Kurashiki, 701-0192, Okayama, Japan aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/2(2011-02-01), 465-471 0163-2116 56:2<465 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer