caa a22 4500 445797681 CHVBK 20180317145131.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10620-011-1783-y doi (NATIONALLICENCE)springer-10.1007/s10620-011-1783-y Prodromal Irritable Bowel Syndrome May Be Responsible for Delays in Diagnosis in Patients Presenting with Unrecognized Crohn's Disease and Celiac Disease, but Not Ulcerative Colitis [Elektronische Daten] [S. Barratt, J. Leeds, K. Robinson, A. Lobo, M. McAlindon, D. Sanders] Introduction: We aimed to determine the prevalence and duration of prodromal periods in patients with celiac disease and inflammatory bowel disease (Crohn's disease and ulcerative colitis). Furthermore, we explored to what extent vague abdominal symptoms consistent with both disorders were attributed to irritable bowel syndrome (IBS) and if the presence of prodromal IBS (P-IBS) had an impact on prodrome duration. Methods: In the study, 683 biopsy-proven patients (celiac n=225, ulcerative colitis n=228, Crohn's disease n=230) completed a postal survey including an assessment of prodromal periods and IBS symptoms during both the prodrome and at present (achieved by completion of the ROME II criteria). Results were compared to age/sex-matched controls (n=348). Results: Crohn's disease patients had the highest prevalence of prodromes (94%) in comparison to ulcerative colitis (48%) and celiac disease (44%). However, Crohn's disease patients have the lowest prevalence of P-IBS (29%) in comparison to ulcerative colitis (38%) and celiac disease (67%). Prodrome duration in patients with P-IBS Crohn's disease was 4years in comparison to 2years without (p=0.018). Prodrome duration in P-IBS celiac disease was 10years in comparison to 7years without (p=0.046). Prodrome duration in patients with ulcerative colitis was not affected by P-IBS (p≥0.05). Age and sex were not confounding factors. Conclusions: This is the first study to make direct comparisons of prodrome periods between celiac disease and IBD. Prodrome duration in celiac disease is significantly longer and more often characterized by P-IBS than IBD. In celiac disease and CD, P-IBS increases prodrome duration. This may represent a failure to understand the overlap between IBS and celiac disease/IBD. Springer Science+Business Media, LLC, 2011 Celiac disease nationallicence Inflammatory bowel disease nationallicence Prodrome nationallicence Irritable bowel syndrome nationallicence Barratt S. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut Leeds J. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut Robinson K. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut Lobo A. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut McAlindon M. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut Sanders D. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3270-3275 0163-2116 56:11<3270 2011 56 10620 https://doi.org/10.1007/s10620-011-1783-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1783-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barratt S. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut NATIONALLICENCE 700 1- Leeds J. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut NATIONALLICENCE 700 1- Robinson K. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut NATIONALLICENCE 700 1- Lobo A. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut NATIONALLICENCE 700 1- McAlindon M. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut NATIONALLICENCE 700 1- Sanders D. The Gastroenterology & Liver Unit, Sheffield Teaching Hospitals NHS Foundation Trust, S10 2JF, Sheffield, UK aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3270-3275 0163-2116 56:11<3270 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer