caa a22 4500 445797762 CHVBK 20180317145131.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10620-011-1722-y doi (NATIONALLICENCE)springer-10.1007/s10620-011-1722-y Hepatic Osteodystrophy Is Common in Patients with Noncholestatic Liver Disease [Elektronische Daten] [N. Choudhary, M. Tomar, Y. Chawla, S. Bhadada, N. Khandelwal, R. Dhiman, A. Duseja, A. Bhansali] Background: Patients with cirrhosis are more prone to develop metabolic bone disease. Scanty literature data are available on osteodystrophy in patients from India with noncholestatic liver diseases. Methods: Patients diagnosed with cirrhosis were prospectively evaluated for bone mineral density (BMD) as measured by dual-energy X-ray absorptiometry at the femoral neck, lumbar spine, and left forearm (distal radius). Correlation of BMD with age, sex, etiology of cirrhosis, Child's class, serum bilirubin, alkaline phosphatase (ALP), albumin, calcium, phosphate, 25-hydroxyvitamin D (25(OH)D), and parathyroid hormone (PTH) was studied. Results: The study group comprised 115 cirrhotic patients (107 males and 8 females). Etiology of cirrhosis was alcohol in 67 (58.2%) and viral in 48 (41.7%). Hepatitis B was diagnosed in 29 (25.2%) and hepatitis C in 19 (16.5%). Mean age was 49 (±5.5) years. Prevalence of osteodystrophy was significantly higher in males than in females; 97.1% and 75% respectively (P=.038). Both alcoholic and viral groups had similar baseline characteristics except albumin levels. Child's class was B in 72 patients and C in 43. Low BMD was present in 97% of patients with alcoholic cirrhosis and 93.7% with viral cirrhosis (P>.05). Low BMD was present at the femoral neck in 80.8% of patients, lumbar spine in 77.3%, and forearm in 59.9%. PTH correlated negatively with BMD. Conclusion: Osteodystrophy is common in alcoholic and viral cirrhosis patients. Springer Science+Business Media, LLC, 2011 Bone nationallicence Cirrhosis nationallicence Osteoporosis nationallicence Etiology nationallicence Choudhary N. Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut Tomar M. Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut Chawla Y. Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut Bhadada S. Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut Khandelwal N. Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut Dhiman R. Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut Duseja A. Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut Bhansali A. Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3323-3327 0163-2116 56:11<3323 2011 56 10620 https://doi.org/10.1007/s10620-011-1722-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1722-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Choudhary N. Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut NATIONALLICENCE 700 1- Tomar M. Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut NATIONALLICENCE 700 1- Chawla Y. Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut NATIONALLICENCE 700 1- Bhadada S. Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut NATIONALLICENCE 700 1- Khandelwal N. Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut NATIONALLICENCE 700 1- Dhiman R. Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut NATIONALLICENCE 700 1- Duseja A. Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut NATIONALLICENCE 700 1- Bhansali A. Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3323-3327 0163-2116 56:11<3323 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer