caa a22 4500 445797797 CHVBK 20180317145131.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10620-011-1758-z doi (NATIONALLICENCE)springer-10.1007/s10620-011-1758-z Gastric Juice Prostaglandins and Peptide Growth Factors as Potential Markers of Chronic Atrophic Gastritis, Intestinal Metaplasia and Gastric Cancer: Their Potential Clinical Implications Based on this Pilot Study [Elektronische Daten] [Ajoy Dias, Cesar Garcia, Marek Majewski, Grzegorz Wallner, Richard McCallum, Cezary Poplawski, Jerzy Sarosiek] Background: Gastric secretion can provide valuable information especially when Helicobacter pylori (Hp) infection results in chronic atrophic gastritis (CAG) and intestinal metaplasia (IM) preceding adenocarcinoma (AdCa). Aims: Looking for a potential biomarker of malignant transformation in the setting of chronic inflammation we studied the levels of prostaglandin E2 (PGE2), as well as peptide growth factors [epidermal growth factor (EGF) and transforming growth factor α (TGFα)], harbingers of injury and repair, in gastric juice aspirated at endoscopy from patients with CAG, CAG/IM, AdCa, and controls. Methods: The PGE2, EGF and TGFα concentrations in the gastric juice were measured using radioimmunoassays (RIAs). Results: In patients with AdCa gastric juice PGE2 increased fivefold versus controls (P<0.01) and almost threefold versus patients with CAG (P<0.05). The EGF levels in patients with AdCa were fourfold higher versus controls (P<0.001) and almost threefold higher versus CAG (P<0.05). In patients with CAG/IM the EGF levels were also almost 3 times higher versus controls. The TGFα levels in patients with AdCa were half the value of controls and CAG (P<0.05). In patients with CAG/IM the levels were as low as 1/5 of controls or CAG (P<0.05). Conclusions: Testing the gastric juice for PGE2, EGF, and TGFα in patients with endoscopy and biopsy proven CAG, may be helpful in follow up of patients who may potentially progress to IM and ultimately AdCa. This could be considered as an adjunct to histologic assessment especially that even the best surveillance biopsy specimen regimens are inherited with sampling errors. The Author(s), 2011 Gastritis nationallicence Intestinal metaplasia nationallicence Adenocarcinoma nationallicence Helicobacter pylori nationallicence Prostaglandins nationallicence Peptide growth factors nationallicence Dias Ajoy Department of Internal Medicine, TTUHSC Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, 79905-2709, El Paso, TX, USA aut Garcia Cesar Department of Internal Medicine, TTUHSC Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, 79905-2709, El Paso, TX, USA aut Majewski Marek Medical University of Lublin, Lublin, Poland aut Wallner Grzegorz Medical University of Lublin, Lublin, Poland aut McCallum Richard Department of Internal Medicine, TTUHSC Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, 79905-2709, El Paso, TX, USA aut Poplawski Cezary Collegium Medicum, UMK, Bydgoszcz, Poland aut Sarosiek Jerzy Department of Internal Medicine, TTUHSC Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, 79905-2709, El Paso, TX, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3220-3225 0163-2116 56:11<3220 2011 56 10620 https://doi.org/10.1007/s10620-011-1758-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1758-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dias Ajoy Department of Internal Medicine, TTUHSC Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, 79905-2709, El Paso, TX, USA aut NATIONALLICENCE 700 1- Garcia Cesar Department of Internal Medicine, TTUHSC Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, 79905-2709, El Paso, TX, USA aut NATIONALLICENCE 700 1- Majewski Marek Medical University of Lublin, Lublin, Poland aut NATIONALLICENCE 700 1- Wallner Grzegorz Medical University of Lublin, Lublin, Poland aut NATIONALLICENCE 700 1- McCallum Richard Department of Internal Medicine, TTUHSC Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, 79905-2709, El Paso, TX, USA aut NATIONALLICENCE 700 1- Poplawski Cezary Collegium Medicum, UMK, Bydgoszcz, Poland aut NATIONALLICENCE 700 1- Sarosiek Jerzy Department of Internal Medicine, TTUHSC Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, 79905-2709, El Paso, TX, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3220-3225 0163-2116 56:11<3220 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer