caa a22 4500 445797835 CHVBK 20180317145131.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10620-011-1723-x doi (NATIONALLICENCE)springer-10.1007/s10620-011-1723-x Expression of ADAMTS12 in Colorectal Cancer-Associated Stroma Prevents Cancer Development and Is a Good Prognostic Indicator of Colorectal Cancer [Elektronische Daten] [Da Wang, Tao Zhu, Fu-Biao Zhang, Chao He] Aim: The aim of this study was to investigate the role of ADAMTS12 in colorectal cancer progression and to examine whether ADAMTS-12 can be considered as a prognostic indicator for colorectal cancer. Methods: This study was performed on formalin-fixed paraffin-embedded resected specimens obtained from 112 patients with colorectal cancer. The expression level of ADAMTS12 was investigated by immunohistochemical staining to assess the relationship between ADAMTS12 expression and the clinicopathologic factors and to study the prognostic significance of ADAMTS12 in colorectal cancer patients. Results: ADAMTS12 expression was mainly localized in the fibroblasts adjacent to the tumor cells or in macrophages in front of the invasive cancer margins. The ADAMTS12 expression was significantly correlated with the tumor histological grade, depth of tumor invasion, lymph node metastasis, and Dukes' stage. Patients with low or no ADAMTS12 expression in the tumor stroma had a significantly poor overall survival or disease-free survival. Conclusion: The expression of ADAMTS12 in colorectal cancer stroma plays an important role in inhibiting tumor development. Patients with ADAMTS12 expression showed better prognosis than those without ADAMTS12 expression. Thus, ADAMTS12 expression may be a good prognostic marker for colorectal cancer. Springer Science+Business Media, LLC, 2011 ADAMTS12 nationallicence Colorectal cancer nationallicence Stroma nationallicence Prognosis nationallicence Wang Da Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine/SRRSH, 3 East Qingchun Road, 310006, Hangzhou, Zhejiang, People's Republic of China aut Zhu Tao Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China aut Zhang Fu-Biao Biomedical Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China aut He Chao Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine/SRRSH, 3 East Qingchun Road, 310006, Hangzhou, Zhejiang, People's Republic of China aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3281-3287 0163-2116 56:11<3281 2011 56 10620 https://doi.org/10.1007/s10620-011-1723-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1723-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Da Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine/SRRSH, 3 East Qingchun Road, 310006, Hangzhou, Zhejiang, People's Republic of China aut NATIONALLICENCE 700 1- Zhu Tao Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Fu-Biao Biomedical Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China aut NATIONALLICENCE 700 1- He Chao Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine/SRRSH, 3 East Qingchun Road, 310006, Hangzhou, Zhejiang, People's Republic of China aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3281-3287 0163-2116 56:11<3281 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer