caa a22 4500 445797851 CHVBK 20180317145131.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10620-011-1726-7 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1726-7 Serotonin Transporter and G Protein Beta 3 Subunit Gene Polymorphisms in Greeks with Irritable Bowel Syndrome [Elektronische Daten] [T. Markoutsaki, T. Karantanos, M. Gazouli, N. Anagnou, S. Ladas, D. Karamanolis] Background: Polymorphisms in the serotonin transporter (SERT) and G protein β3 subunit (GNB3) genes might contribute to the pathophysiology of irritable bowel syndrome (IBS). Association studies of SERT and GNB3 polymorphisms and IBS have shown diverse results among different populations, which might be due to subject composition differences. Aims: The aim of the study was to assess the potential association between SERT and GNB3 polymorphisms and IBS in Greeks. Methods: A total of 124 patients with IBS diagnosed according to the Rome III criteria and 238 healthy individuals were included in the study. SERT and GNB3 gene polymorphisms were genotyped using polymerase chain reaction-based methods. Results: It was shown that the frequencies of the SS genotype and S allele of the serotonin transporter polymorphism were significantly associated with IBS (P=0.0314 and P=0.019, respectively). TT genotype and T allele frequencies of G protein β3 subunit showed also significant difference between the IBS patients and healthy controls IBS (P=0.0163 and P=0.0001, respectively). None of the clinical symptoms analyzed was significantly associated with the polymorphisms tested. Conclusions: The results suggest that SERT and GNB3 gene polymorphisms might be associated with irritable bowel syndrome predisposition in Greeks. Springer Science+Business Media, LLC, 2011 IBS nationallicence SERT nationallicence GNB3 nationallicence SNPs nationallicence Markoutsaki T. 2nd Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece aut Karantanos T. Department of Basic Sciences, Laboratory of Biology, School of Medicine, University of Athens, Michalakopoulou 176, 11527, Athens, Greece aut Gazouli M. Department of Basic Sciences, Laboratory of Biology, School of Medicine, University of Athens, Michalakopoulou 176, 11527, Athens, Greece aut Anagnou N. Department of Basic Sciences, Laboratory of Biology, School of Medicine, University of Athens, Michalakopoulou 176, 11527, Athens, Greece aut Ladas S. Gastroenterology Division, 1st Propaedeutic Department of Internal Medicine, School of Medicine, Laikon Hospital, University of Athens, Athens, Greece aut Karamanolis D. 2nd Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3276-3280 0163-2116 56:11<3276 2011 56 10620 https://doi.org/10.1007/s10620-011-1726-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1726-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Markoutsaki T. 2nd Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece aut NATIONALLICENCE 700 1- Karantanos T. Department of Basic Sciences, Laboratory of Biology, School of Medicine, University of Athens, Michalakopoulou 176, 11527, Athens, Greece aut NATIONALLICENCE 700 1- Gazouli M. Department of Basic Sciences, Laboratory of Biology, School of Medicine, University of Athens, Michalakopoulou 176, 11527, Athens, Greece aut NATIONALLICENCE 700 1- Anagnou N. Department of Basic Sciences, Laboratory of Biology, School of Medicine, University of Athens, Michalakopoulou 176, 11527, Athens, Greece aut NATIONALLICENCE 700 1- Ladas S. Gastroenterology Division, 1st Propaedeutic Department of Internal Medicine, School of Medicine, Laikon Hospital, University of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Karamanolis D. 2nd Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3276-3280 0163-2116 56:11<3276 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer