caa a22 4500 445797983 CHVBK 20180317145132.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10620-011-1756-1 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1756-1 Prevalence of Autoimmune Liver Disease Related Autoantibodies in Chinese Patients with Primary Biliary Cirrhosis [Elektronische Daten] [Chaojun Hu, Chuiwen Deng, Guang Song, Wen Zhang, Shulan Zhang, Xi Li, Ping Li, Fengchun Zhang, Yongzhe Li] Background: The prevalence of autoimmune liver disease (AiLD)-related autoantibodies has not been defined in Chinese patients with primary biliary cirrhosis (PBC) and therefore needs to be characterized. Aims: The purpose of this study was to explore the prevalence of AiLD-related autoantibodies in Chinese patients with PBC. Methods: Indirect immunofluorescence was used to detect anti-mitochondrial antibodies (AMA) in the sera from 198 PBC, 44 autoimmune hepatitis (AIH) and 41 non-autoimmune liver disease controls (LDC). ELISA assays were used to test the presence of anti-M2, anti-gp210, anti-sp100, anti-SLA, anti-LC1 and anti-LKM-1 antibodies. Results: AMA was present in 92.4, 15.9 and 7.3%, respectively, of patients with PBC, AIH and LDC. Anti-M2 was present in 87.4% of the PBC patients, but only in 4.5 and 4.9%, respectively, of AIH and LDC patients. Anti-gp210 and anti-sp100 were detected in 34.3 and 25.8% of PBC, 6.8 and 15.9% of AIH and in 4.9 and 17.1% of LDC patients. Anti-LC1, anti-SLA and anti-LKM-1 were, respectively, present in 1.5, 0.0 and 0.5% of PBC, and 9.1, 11.4 and 2.3% of AIH, and none of LDC. PBC patients that were AMA-positive presented with higher IgM levels but lower CRP levels than negative ones. ALT, TBIL, DBIL, GGT, ALP, and AST were detected at higher levels and ALB at lower levels in PBC positive for anti-gp210 (P<0.05). Conclusions: The prevalence of AiLD-related autoantibodies we provided might help define PBC in China. Anti-sp100 is not a better prognostic marker for Chinese PBC patients compared to anti-gp210. The identification of effective diagnostic biomarkers for AMA-negative PBC patients is still needed. Springer Science+Business Media, LLC, 2011 Primary biliary cirrhosis nationallicence Autoimmune liver diseases nationallicence Autoantibodies nationallicence Diagnostic markers nationallicence Hu Chaojun Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut Deng Chuiwen Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut Song Guang Beijing Institute of Genomics, Chinese Academy of Sciences, B-6 Airport Industrial Zone, 101318, Beijing, People's Republic of China aut Zhang Wen Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut Zhang Shulan Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut Li Xi Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut Li Ping Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut Zhang Fengchun Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut Li Yongzhe Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3357-3363 0163-2116 56:11<3357 2011 56 10620 https://doi.org/10.1007/s10620-011-1756-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1756-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hu Chaojun Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Deng Chuiwen Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Song Guang Beijing Institute of Genomics, Chinese Academy of Sciences, B-6 Airport Industrial Zone, 101318, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Wen Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Shulan Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Li Xi Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Li Ping Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Fengchun Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Li Yongzhe Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.41 Da Mu Cang, Western District, 100032, Beijing, People's Republic of China aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; 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