caa a22 4500 445798025 CHVBK 20180317145132.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10620-011-1755-2 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1755-2 Gastric Emptying and Intestinal Transit of Various Enteral Feedings Following Severe Burn Injury [Elektronische Daten] [Hanaa Sallam, George Kramer, Jiande Chen] Background: Burn-induced delayed gastric emptying and intestinal transit limits enteral feeding/resuscitation. Aims: To study (1) the effects of burn injury on gastric emptying and intestinal transit at different time points following enteral feeding/fluids, and (2) the effects of enteral resuscitative fluids on gastric emptying, intestinal transit, and plasma volume expansion. Methods: Rats were randomized into sham-burn and burn groups. They were either enterally untreated or treated by a gavage of one or multiple doses of oral rehydration solution (ORS) or, Vivonex®, all mixed with phenol red as a marker, at different time points from 1 to 6h after burn. Gastric emptying, intestinal transit and hematocrit values were assessed. Gastric emptying of a semi-solid methylcellulose meal served as a standard control for gastric emptying studies. Results: We found that (1) burn did not alter the gastric emptying of ORS, but delayed its intestinal transit at all time points; (2) burn delayed the gastric emptying of both methylcellulose or Vivonex and the intestinal transit of Vivonex, 6h after burn; and (3) multiple doses of ORS normalized the elevated post-burn hematocrit values. The percentage of plasma volume expansion at 6h resulting from the multiple-dose ORS was superior to that of Vivonex by 50%. Addition of Erythromycin to Vivonex improved its gastric emptying, intestinal transit, and plasma volume expansion. Conclusions: Burn delays the gastric emptying of semi-solids, but not the ORS. Enteral electrolyte solution (ORS) and feeding (Vivonex) provided plasma volume expansion. Prokinetic drugs may be able to maximize the effectiveness of early post-burn feeding. Springer Science+Business Media, LLC, 2011 Burn nationallicence Enteral resuscitation nationallicence Gastric emptying nationallicence Intestinal transit nationallicence ORS nationallicence Vivonex nationallicence Sallam Hanaa Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, 301 University Blvd, 77555-0655, Galveston, TX, USA aut Kramer George Department of Anesthesiology, Resuscitation Research Laboratory, University of Texas Medical Branch, 301 University Blvd, 77555-1102, Galveston, TX, USA aut Chen Jiande Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, 301 University Blvd, 77555-0655, Galveston, TX, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3172-3178 0163-2116 56:11<3172 2011 56 10620 https://doi.org/10.1007/s10620-011-1755-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1755-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sallam Hanaa Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, 301 University Blvd, 77555-0655, Galveston, TX, USA aut NATIONALLICENCE 700 1- Kramer George Department of Anesthesiology, Resuscitation Research Laboratory, University of Texas Medical Branch, 301 University Blvd, 77555-1102, Galveston, TX, USA aut NATIONALLICENCE 700 1- Chen Jiande Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, 301 University Blvd, 77555-0655, Galveston, TX, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/11(2011-11-01), 3172-3178 0163-2116 56:11<3172 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer