caa a22 4500 445798130 CHVBK 20180317145132.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s11017-010-9170-9 doi (NATIONALLICENCE)springer-10.1007/s11017-010-9170-9 Stanev Roger Department of Philosophy, University of British Columbia, 1866 Main Mall E370, V6T 1Z1, Vancouver, BC, Canada aut Statistical decisions and the interim analyses of clinical trials [Elektronische Daten] [Roger Stanev] This paper analyzes statistical decisions during the interim analyses of clinical trials. After some general remarks about the ethical and scientific demands of clinical trials, I introduce the notion of a hard-case clinical trial, explain the basic idea behind it, and provide a real example involving the interim analyses of zidovudine in asymptomatic HIV-infected patients. The example leads me to propose a decision analytic framework for handling ethical conflicts that might arise during the monitoring of hard-case clinical trials. I use computer simulations to show how the framework can assist in reconciling certain ethical conflicts. The framework is partial, lacking the precision of a complete systematization of statistical monitoring procedures in practice. Springer Science+Business Media B.V., 2011 Evidence nationallicence Statistical inference nationallicence Confirmation nationallicence Bayesian nationallicence Case study nationallicence HIV/AIDS nationallicence Theoretical Medicine and Bioethics Springer Netherlands 32/1(2011-02-01), 61-74 1386-7415 32:1<61 2011 32 11017 https://doi.org/10.1007/s11017-010-9170-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11017-010-9170-9 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Stanev Roger Department of Philosophy, University of British Columbia, 1866 Main Mall E370, V6T 1Z1, Vancouver, BC, Canada aut NATIONALLICENCE 773 0- Theoretical Medicine and Bioethics Springer Netherlands 32/1(2011-02-01), 61-74 1386-7415 32:1<61 2011 32 11017 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer