caa a22 4500 445799218 CHVBK 20180317145135.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00053-011-0177-0 doi (NATIONALLICENCE)springer-10.1007/s00053-011-0177-0 Effect of Lactobacillus casei Shirota on colonic transit time in patients with chronic constipation [Elektronische Daten] [H.-J. Krammer, H. von Seggern, J. Schaumburg, F. Neumer] Auswirkung von Lactobacillus casei Shirota auf die Transitzeit bei Patienten mit chronischer Obstipation Background: Slow-transit constipation (STC) is caused by a motility disorder of the colon which leads to delayed transit (>72h). The probiotic strain Lactobacillus casei Shirota (LcS) has been shown to improve constipation-related symptoms, such as stool frequency and consistency. A randomized double-blind placebo-controlled trial was performed to determine the effect of LcS on the colonic transit time in patients with STC. Patients and methods: Colonic transit time of all consecutive outpatients with chronic constipation was determined by the Hinton test using radiopaque markers. Patients with a transit time longer than 72h were included in the study. A total of 24 patients received either a dairy drink containing 6.5×109 colony forming units (cfu) of LcS or a placebo daily for 4 weeks. General gastrointestinal symptoms were evaluated weekly by a questionnaire and the measurement of colonic transit time was repeated after the intervention. Results: The intake of LcS resulted in a significant acceleration of the total colonic transit time from 95.6h to 76.5h (p=0.05). This effect was most pronounced in the sigmoid and rectum transit time (p<0.007). In the placebo group no statistically significant change in the total colonic transit time was observed (before: 95.8h, after: 87.1h, p=0.282) Conclusion: The daily intake of a probiotic drink containing LcS significantly reduced the colonic transit time in patients with STC. Urban &amp; Vogel, Muenchen, 2011 Probiotics nationallicence Constipation nationallicence Transit time nationallicence Shirota nationallicence Clinical trial nationallicence Probiotika nationallicence Obstipation nationallicence Transitzeit nationallicence Shirota nationallicence Klinische Studie nationallicence Krammer H.-J Praxis für Gastroenterologie und Ernährungsmedizin am End- und Dickdarmzentrum Mannheim, Bismarckplatz 1, 68165, Mannheim, Deutschland aut von Seggern H. Praxis für Gastroenterologie und Ernährungsmedizin am End- und Dickdarmzentrum Mannheim, Bismarckplatz 1, 68165, Mannheim, Deutschland aut Schaumburg J. Yakult Deutschland GmbH, Neuss, Deutschland aut Neumer F. Praxis für Gastroenterologie und Ernährungsmedizin am End- und Dickdarmzentrum Mannheim, Bismarckplatz 1, 68165, Mannheim, Deutschland aut coloproctology Springer-Verlag 33/2(2011-04-01), 109-113 0174-2442 33:2<109 2011 33 53 https://doi.org/10.1007/s00053-011-0177-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00053-011-0177-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Krammer H.-J Praxis für Gastroenterologie und Ernährungsmedizin am End- und Dickdarmzentrum Mannheim, Bismarckplatz 1, 68165, Mannheim, Deutschland aut NATIONALLICENCE 700 1- von Seggern H. Praxis für Gastroenterologie und Ernährungsmedizin am End- und Dickdarmzentrum Mannheim, Bismarckplatz 1, 68165, Mannheim, Deutschland aut NATIONALLICENCE 700 1- Schaumburg J. Yakult Deutschland GmbH, Neuss, Deutschland aut NATIONALLICENCE 700 1- Neumer F. Praxis für Gastroenterologie und Ernährungsmedizin am End- und Dickdarmzentrum Mannheim, Bismarckplatz 1, 68165, Mannheim, Deutschland aut NATIONALLICENCE 773 0- coloproctology Springer-Verlag 33/2(2011-04-01), 109-113 0174-2442 33:2<109 2011 33 53 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer