caa a22 4500 445801174 CHVBK 20180317145141.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10337-010-1871-8 doi (NATIONALLICENCE)springer-10.1007/s10337-010-1871-8 Derivatization Method for Determination of Nitrosamines by GC-MS [Elektronische Daten] [Xiang Wang, Yihan Gao, Xuejiao Xu, Jianfeng Zhao, Guoxin Song, Yaoming Hu] Gas chromatography/low-resolution mass spectrometry with electron impact source was applied to detect eight nitrosamines (NAs). NAs were first denitrosated by a mixed solution of hydrobromic and acetic acids, followed by sulfonylation with p-toluenesulfonyl chloride. Variables affecting the denitrosation and sulfonylation, such as temperature, time, pH and reagent concentration, were optimized. Comparison of the determination of NAs with and without derivatization was performed. Results showed that better chromatographic behavior and larger mass response were obtained after derivatization, and instrumental detection limits ranged from 0.016 to 0.053ng, a nearly 20-fold decrease of those without derivatization. The proposed method provided an alternative to performing accurate qualitative and quantitative analysis of NAs with expensive high-resolution mass spectrometry or thermal energy analyzer. Springer-Verlag, 2011 Gas chromatography nationallicence Low-resolution mass spectrometer nationallicence Denitrosation nationallicence Sulfonylation nationallicence N -Nitrosamine nationallicence Wang Xiang Shanghai Institute of Occupational Disease for Chemical Industry, 200041, Shanghai, People's Republic of China aut Gao Yihan The Research Center of Analysis and Measurement, Fudan University, 200433, Shanghai, People's Republic of China aut Xu Xuejiao The Research Center of Analysis and Measurement, Fudan University, 200433, Shanghai, People's Republic of China aut Zhao Jianfeng The Research Center of Analysis and Measurement, Fudan University, 200433, Shanghai, People's Republic of China aut Song Guoxin The Research Center of Analysis and Measurement, Fudan University, 200433, Shanghai, People's Republic of China aut Hu Yaoming The Research Center of Analysis and Measurement, Fudan University, 200433, Shanghai, People's Republic of China aut Chromatographia Vieweg Verlag 73/3-4(2011-02-01), 321-327 0009-5893 73:3-4<321 2011 73 10337 https://doi.org/10.1007/s10337-010-1871-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-010-1871-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Xiang Shanghai Institute of Occupational Disease for Chemical Industry, 200041, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Gao Yihan The Research Center of Analysis and Measurement, Fudan University, 200433, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Xu Xuejiao The Research Center of Analysis and Measurement, Fudan University, 200433, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Zhao Jianfeng The Research Center of Analysis and Measurement, Fudan University, 200433, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Song Guoxin The Research Center of Analysis and Measurement, Fudan University, 200433, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Hu Yaoming The Research Center of Analysis and Measurement, Fudan University, 200433, Shanghai, People's Republic of China aut NATIONALLICENCE 773 0- Chromatographia Vieweg Verlag 73/3-4(2011-02-01), 321-327 0009-5893 73:3-4<321 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer