caa a22 4500 445801654 CHVBK 20180317145143.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10337-011-1968-8 doi (NATIONALLICENCE)springer-10.1007/s10337-011-1968-8 From Csaba Horváth to Quality by Design: Visualizing Design Space in Selectivity Exploration of HPLC Separations [Elektronische Daten] [I. Molnár, K. Monks] The present paper starts by taking a look back at some of the pioneering work in high pressure liquid chromatography (HPLC) that went on in Csaba Horváth's laboratory in 1970s, through the eyes of I. Molnár. It then goes on to describe a very modern approach to HPLC method development within the Quality by Design framework: the multifactorial optimization of three critical HPLC method parameters, i.e. gradient time (t G), temperature (T), and ternary composition (B1:B2) based on 12 experiments. The effect of these experimental variables on critical resolution and selectivity was carried out in such a way as to systematically vary all three factors simultaneously. Springer-Verlag, 2011 Csaba Horváth nationallicence Solvophobic theory nationallicence Quality by Design nationallicence Design space nationallicence 3D computer modeling software nationallicence Molnár I. Molnár-Institute for Applied Chromatography, Schneeglöckchenstr.47, 10407, Berlin, Germany aut Monks K. Molnár-Institute for Applied Chromatography, Schneeglöckchenstr.47, 10407, Berlin, Germany aut Chromatographia Springer-Verlag 73(2011-06-01), 5-14 0009-5893 73<5 2011 73 10337 https://doi.org/10.1007/s10337-011-1968-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-1968-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Molnár I. Molnár-Institute for Applied Chromatography, Schneeglöckchenstr.47, 10407, Berlin, Germany aut NATIONALLICENCE 700 1- Monks K. Molnár-Institute for Applied Chromatography, Schneeglöckchenstr.47, 10407, Berlin, Germany aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73(2011-06-01), 5-14 0009-5893 73<5 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer