caa a22 4500 445801662 CHVBK 20180317145143.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10337-010-1880-7 doi (NATIONALLICENCE)springer-10.1007/s10337-010-1880-7 Rapid Resolution Liquid chromatography/High Resolution Tandem Mass Spectrometry to Characterize Metabolic Changes in Subjects Involved in MARS500 Project [Elektronische Daten] [Anna Capriotti, Giuseppe Caruso, Chiara Cavaliere, Patrizia Foglia, Mariano Bizzarri, Aldo Laganà] A rapid resolution liquid chromatography-tandem mass spectrometry analysis was applied to human urine samples to discover new molecular biomarkers of the alteration of psychophysical well-being due to the environmental, physiological and confinement stress conditions achieved in the MARS500 project. Urine samples of crew members were submitted to metabolomic studies by means of separative techniques coupled with mass spectrometric techniques and data analysis. More than 2,000 metabolite features were found in each comparison, and more than 150 metabolites were identified for every differential analysis. Significant modifications in eight metabolites were shared by the subjects under study. Springer-Verlag, 2011 Column liquid chromatography nationallicence Tandem mass spectrometry nationallicence Differential metabolomics nationallicence Human metabolism nationallicence Urine nationallicence Confinement stress nationallicence GSA : Guanido-succinic acid nationallicence MFG : Molecular formula generator nationallicence OMP : Oritidine monophosphate nationallicence Q-TOF : Quadrupole-time of flight nationallicence RRLC : Rapid resolution liquid chromatography nationallicence TG : Testosterone glucuronide nationallicence UMP : Uridine monophosphate nationallicence Capriotti Anna Department of Chemistry, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut Caruso Giuseppe Department of Chemistry, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut Cavaliere Chiara Department of Chemistry, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut Foglia Patrizia Department of Chemistry, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut Bizzarri Mariano Department of Experimental Medicine, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut Laganà Aldo Department of Chemistry, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut Chromatographia Springer-Verlag 73(2011-06-01), 45-53 0009-5893 73<45 2011 73 10337 https://doi.org/10.1007/s10337-010-1880-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-010-1880-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Capriotti Anna Department of Chemistry, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Caruso Giuseppe Department of Chemistry, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Cavaliere Chiara Department of Chemistry, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Foglia Patrizia Department of Chemistry, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Bizzarri Mariano Department of Experimental Medicine, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Laganà Aldo Department of Chemistry, "Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73(2011-06-01), 45-53 0009-5893 73<45 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer