caa a22 4500 445801824 CHVBK 20180317145143.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10337-011-1991-9 doi (NATIONALLICENCE)springer-10.1007/s10337-011-1991-9 Enantioseparation of 1-Phenyl-1,2,3,4-tetrahydroisoquinoline on Polysaccharide-Based Chiral Stationary Phases [Elektronische Daten] [Helena Kažoka, Oksana Rotkaja, Larisa Varačeva] The enantiomers of 1-phenyl-1,2,3,4-tetrahydroisoquinoline have been directly separated on polysaccharide-based chiral stationary phases (CSPs). The normal phase separation of (S)- and (R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline was accomplished by screening of the immobilized Chiralpak IC column with different eluents. The effect of mobile phase type on retention, selectivity and resolution was studied. 2-Propanol or ethanol/n-hexane/ethanolamine mixtures were applied as mobile phases by screening of following polysaccharide-based immobilized (Chiralpak IA, Chiralpak IC) and coated (Lux Cellulose-1, Lux Cellulose-2, Lux Amylose-2) CSPs. Polar organic and reversed-phase conditions were also tested for direct enantioseparation of 1-phenyl-1,2,3,4-tetrahydroisoquinoline. Springer-Verlag, 2011 Column liquid chromatography nationallicence Enantioseparation nationallicence Polysaccharide-based chiral stationary phases nationallicence 1-Phenyl-1,2,3,4-tetrahydroisoquinoline nationallicence Kažoka Helena Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, 1006, Riga, Latvia aut Rotkaja Oksana Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, 1006, Riga, Latvia aut Varačeva Larisa Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, 1006, Riga, Latvia aut Chromatographia Springer-Verlag 73(2011-06-01), 123-129 0009-5893 73<123 2011 73 10337 https://doi.org/10.1007/s10337-011-1991-9 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-1991-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kažoka Helena Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, 1006, Riga, Latvia aut NATIONALLICENCE 700 1- Rotkaja Oksana Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, 1006, Riga, Latvia aut NATIONALLICENCE 700 1- Varačeva Larisa Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, 1006, Riga, Latvia aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73(2011-06-01), 123-129 0009-5893 73<123 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer