caa a22 4500 445801859 CHVBK 20180317145143.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10337-011-1933-6 doi (NATIONALLICENCE)springer-10.1007/s10337-011-1933-6 The Optimal Control of Geometry and Voltage Parameters on Electrokinetic Transport to Avoid Sample Leakage in Microfluidic Chips [Elektronische Daten] [Min-Hui Yang, Shau-Chun Wang, Jen-Chieh Cheng] Computer simulation is used to investigate sample transport phenomena of cross microfluidic chips. In this study, Kirchhoff circuit theory is employed to calculate the electric field strength and approximate electroosmotic flow. It is apparent from the results that both the simulation and the theoretical data show similar trends in the electroosmosis of cross microchips. The main target in this study is to summarize the optimal controlling parameter values for avoiding sample leakage in the transport process. The effects of the applied voltage ratio, the geometry ratio and the zeta potential were simulated using a computational fluid dynamics and multiphysics solver software package (CFD-ACE+). Under our designed conditions, two major conclusions were reached: (1) for high-voltage ratios, the sample leakage can be avoided as the geometry ratio is large enough at 0.5 or greater, and (2) for small geometries, maintaining a smaller voltage ratio, 0.3 or less, is essential for avoiding sample leakage. The key is to govern the sample velocity in the upstream faster than that in the downstream. Although real experimental conditions can be further fine tuned under microscopy monitoring, these conclusions are helpful to design the proper channel geometry and set up suitable voltage parameters to avoid sample leakages in one cross-channel chip. Springer-Verlag, 2011 Microfluidic chip nationallicence Electroosmotic flow nationallicence Sample leakage nationallicence Yang Min-Hui Department of Biotechnology, National Formosa University, Yunlin, Taiwan aut Wang Shau-Chun Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, Taiwan aut Cheng Jen-Chieh Department of Aeronautical Engineering, National Formosa University, Yunlin, Taiwan aut Chromatographia Springer-Verlag 73/5-6(2011-03-01), 567-577 0009-5893 73:5-6<567 2011 73 10337 https://doi.org/10.1007/s10337-011-1933-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-1933-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Min-Hui Department of Biotechnology, National Formosa University, Yunlin, Taiwan aut NATIONALLICENCE 700 1- Wang Shau-Chun Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, Taiwan aut NATIONALLICENCE 700 1- Cheng Jen-Chieh Department of Aeronautical Engineering, National Formosa University, Yunlin, Taiwan aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73/5-6(2011-03-01), 567-577 0009-5893 73:5-6<567 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer