caa a22 4500 445801875 CHVBK 20180317145143.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10337-011-1918-5 doi (NATIONALLICENCE)springer-10.1007/s10337-011-1918-5 LC-APCI-MS Quantitative Analysis of Curcumin in Rabbit Plasma [Elektronische Daten] [Xuezhi Yang, Jianshe Ma, Yun Ye, Yuan Zhang, Guanyang Lin, Yuancai Zheng, Xu Li, Xianqin Wang] A simple and specific liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (LC-APCI-MS) method was developed and validated for quantitative analysis of curcumin in rabbit plasma. Chromatographic separation was carried out on Zorbax SB-C18 column, acetonitrile-methanol-water used as mobile phase with gradient elution. APCI source was applied and operated in negative ion mode, and selective ion monitoring mode used to quantify curcumin. The method showed excellent intra-assay and inter-assay precision (relative standard deviations and bias <15%) for quality control (QC) samples. This method was successfully applied to a pharmacokinetic study of curcumin after intravenous administration to rabbits. Springer-Verlag, 2011 Column liquid chromatography nationallicence APCI nationallicence Curcumin nationallicence Plasma nationallicence Yang Xuezhi The First Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, China aut Ma Jianshe School of Basic Medical Sciences of Wenzhou Medical College, 325035, Wenzhou, China aut Ye Yun Analytical and Testing Center of Wenzhou Medical College, 325035, Wenzhou, China aut Zhang Yuan Analytical and Testing Center of Wenzhou Medical College, 325035, Wenzhou, China aut Lin Guanyang The First Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, China aut Zheng Yuancai The First Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, China aut Li Xu School of Basic Medical Sciences of Wenzhou Medical College, 325035, Wenzhou, China aut Wang Xianqin Analytical and Testing Center of Wenzhou Medical College, 325035, Wenzhou, China aut Chromatographia Springer-Verlag 73/5-6(2011-03-01), 605-608 0009-5893 73:5-6<605 2011 73 10337 https://doi.org/10.1007/s10337-011-1918-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-1918-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Xuezhi The First Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, China aut NATIONALLICENCE 700 1- Ma Jianshe School of Basic Medical Sciences of Wenzhou Medical College, 325035, Wenzhou, China aut NATIONALLICENCE 700 1- Ye Yun Analytical and Testing Center of Wenzhou Medical College, 325035, Wenzhou, China aut NATIONALLICENCE 700 1- Zhang Yuan Analytical and Testing Center of Wenzhou Medical College, 325035, Wenzhou, China aut NATIONALLICENCE 700 1- Lin Guanyang The First Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, China aut NATIONALLICENCE 700 1- Zheng Yuancai The First Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, China aut NATIONALLICENCE 700 1- Li Xu School of Basic Medical Sciences of Wenzhou Medical College, 325035, Wenzhou, China aut NATIONALLICENCE 700 1- Wang Xianqin Analytical and Testing Center of Wenzhou Medical College, 325035, Wenzhou, China aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73/5-6(2011-03-01), 605-608 0009-5893 73:5-6<605 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer