caa a22 4500 445801905 CHVBK 20180317145144.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10337-010-1900-7 doi (NATIONALLICENCE)springer-10.1007/s10337-010-1900-7 Separation and Determination of Amitriptyline and Nortriptyline in Biological Samples Using Single-Drop Microextraction with GC [Elektronische Daten] [Ali Sarafraz Yazdi, Nourolhoda Razavi] The combination of liquid phase microextraction (LPME) based on a single drop and gas chromatography flame ionization detector (GC-FID) was used for separation and determination of amitriptyline and nortriptyline in human plasma and urine samples. The sample solution was kept alkaline (pH 12), then a microdrop of organic solvent (isooctane) was suspended in the donor solution; after extraction, the organic microdrop was injected into the GC-FID. Experimental LPME conditions were optimized. Finally, the enrichment factors (89.5-139.0), the relative standard deviation (RSD%, n=5) 1.1-8.5, linearity ranges (0.05-20μgmL−1), and the limits of detections (0.01, 0.02μgmL−1) for selected drugs were evaluated. Springer-Verlag, 2011 Gas chromatography nationallicence Single-drop liquid-phase microextraction nationallicence Amitriptyline nationallicence Nortriptyline nationallicence Biological sample nationallicence Sarafraz Yazdi Ali Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Azadi Sq., Mashhad, Khorasan Razavi, Iran aut Razavi Nourolhoda Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Azadi Sq., Mashhad, Khorasan Razavi, Iran aut Chromatographia Springer-Verlag 73/5-6(2011-03-01), 549-557 0009-5893 73:5-6<549 2011 73 10337 https://doi.org/10.1007/s10337-010-1900-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-010-1900-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sarafraz Yazdi Ali Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Azadi Sq., Mashhad, Khorasan Razavi, Iran aut NATIONALLICENCE 700 1- Razavi Nourolhoda Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Azadi Sq., Mashhad, Khorasan Razavi, Iran aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73/5-6(2011-03-01), 549-557 0009-5893 73:5-6<549 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer