caa a22 4500 445802049 CHVBK 20180317145144.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10337-011-1917-6 doi (NATIONALLICENCE)springer-10.1007/s10337-011-1917-6 Resolution of Racemic Ofloxacin Based on Co-Technology of Bubble Fractionation and Extraction [Elektronische Daten] [Lin Li, FeiPeng Jiao, XinYu Jiang, LingXing Tian, XiaoQing Chen] A method of bubble fractionation, with the help of solvent extraction, was developed for the resolution of racemic ofloxacin (rac OFLX). In this method, dibenzoyl-L-tartaric (L-DBTA), di-(2-ethylhexyl) phosphoric acid (D2EHPA) and sodium lauryl sulfate (SDS) were used as chiral collector, co-extractant and foamer, respectively. Several important parameters influencing the resolution performances, such as pH in aqueous phase, concentration of OFLX, concentration of L-DBTA, concentration of SDS and volume ratio of D2EHPA to n-octanol in solution, were investigated. The optimal resolution conditions were obtained with the aqueous phase pH 7, volume ratio of D2EHPA to n-octanol 6/14 in organic phase, concentration of SDS 0.42mgmL−1, concentration of OFLX 1.67mgmL−1, and concentration of L-DBTA 0.11gmL−1. Under the optimal extraction conditions, the enantiomeric excess value (e.e.%) was 60.08% and the enantioselectivity (α) was 5.58. It was found that the capacity of enantioselective separation can be greatly improved by the co-technology. Springer-Verlag, 2011 Column liquid chromatography nationallicence Bubble fractionation nationallicence OFLX nationallicence Extraction nationallicence Co-technology nationallicence Resolution nationallicence Li Lin School of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China aut Jiao FeiPeng School of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China aut Jiang XinYu School of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China aut Tian LingXing School of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China aut Chen XiaoQing School of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China aut Chromatographia Springer-Verlag 73/5-6(2011-03-01), 423-429 0009-5893 73:5-6<423 2011 73 10337 https://doi.org/10.1007/s10337-011-1917-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-1917-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Lin School of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China aut NATIONALLICENCE 700 1- Jiao FeiPeng School of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China aut NATIONALLICENCE 700 1- Jiang XinYu School of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China aut NATIONALLICENCE 700 1- Tian LingXing School of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China aut NATIONALLICENCE 700 1- Chen XiaoQing School of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73/5-6(2011-03-01), 423-429 0009-5893 73:5-6<423 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer