caa a22 4500 445802073 CHVBK 20180317145144.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10337-011-1914-9 doi (NATIONALLICENCE)springer-10.1007/s10337-011-1914-9 LC Method for the Determination of Rhaponticin in Rat Plasma, Faeces and Urine for Application to Pharmacokinetic Studies [Elektronische Daten] [Yingyong Zhao, Lili Wang, Hua Miao, Charlene Ho, Jing Li, Xianlong Cheng, Yongmin Zhang, Ruichao Lin, Wenji Sun] A simple liquid chromatography (LC) method has been developed and validated to determine rhaponticin in rat plasma, faeces and urine. Chromatographic separation was achieved through mobile phase consisting of acetonitrile and water at a flow rate of 1.0mLmin−1. Rhaponticin was quantified using UV detection at 324nm. The assay was linear over the concentration range of 50-4,000ngmL−1 for plasma, faeces and urine. The intra- and inter-day RSD were less than 10%. The plasma, faeces and urine rhaponticin levels were monitored in rats after oral administration. This simple LC method appears to be useful in the pharmacokinetic investigation of rhaponticin. Springer-Verlag, 2011 Column liquid chromatography nationallicence Rhaponticin nationallicence Pharmacokinetics nationallicence Elimination pathway nationallicence Zhao Yingyong Biomedicine Key Laboratory of Shaanxi Province, The College of Life Sciences, Northwest University, No.229 Taibai North Road, 710069, Xi'an, Shaanxi, China aut Wang Lili Biomedicine Key Laboratory of Shaanxi Province, The College of Life Sciences, Northwest University, No.229 Taibai North Road, 710069, Xi'an, Shaanxi, China aut Miao Hua Nanyang Normal University, No.1 Wolong Road, 473000, Nanyang, Henan, China aut Ho Charlene Department of Nutrition, University of California, One Shields Avenue, 95616-8669, Davis, CA, USA aut Li Jing Biomedicine Key Laboratory of Shaanxi Province, The College of Life Sciences, Northwest University, No.229 Taibai North Road, 710069, Xi'an, Shaanxi, China aut Cheng Xianlong National Institute for the Control of Pharmaceutical and Biological Products, 100050, Beijing, China aut Zhang Yongmin Institut Parisien de Chimie Moléculaire, UMR CNRS 7201, Université Pierre et Marie Curie-Paris 6, 4 place Jussieu, 75005, Paris, France aut Lin Ruichao Biomedicine Key Laboratory of Shaanxi Province, The College of Life Sciences, Northwest University, No.229 Taibai North Road, 710069, Xi'an, Shaanxi, China aut Sun Wenji Biomedicine Key Laboratory of Shaanxi Province, The College of Life Sciences, Northwest University, No.229 Taibai North Road, 710069, Xi'an, Shaanxi, China aut Chromatographia Springer-Verlag 73/5-6(2011-03-01), 599-603 0009-5893 73:5-6<599 2011 73 10337 https://doi.org/10.1007/s10337-011-1914-9 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-1914-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhao Yingyong Biomedicine Key Laboratory of Shaanxi Province, The College of Life Sciences, Northwest University, No.229 Taibai North Road, 710069, Xi'an, Shaanxi, China aut NATIONALLICENCE 700 1- Wang Lili Biomedicine Key Laboratory of Shaanxi Province, The College of Life Sciences, Northwest University, No.229 Taibai North Road, 710069, Xi'an, Shaanxi, China aut NATIONALLICENCE 700 1- Miao Hua Nanyang Normal University, No.1 Wolong Road, 473000, Nanyang, Henan, China aut NATIONALLICENCE 700 1- Ho Charlene Department of Nutrition, University of California, One Shields Avenue, 95616-8669, Davis, CA, USA aut NATIONALLICENCE 700 1- Li Jing Biomedicine Key Laboratory of Shaanxi Province, The College of Life Sciences, Northwest University, No.229 Taibai North Road, 710069, Xi'an, Shaanxi, China aut NATIONALLICENCE 700 1- Cheng Xianlong National Institute for the Control of Pharmaceutical and Biological Products, 100050, Beijing, China aut NATIONALLICENCE 700 1- Zhang Yongmin Institut Parisien de Chimie Moléculaire, UMR CNRS 7201, Université Pierre et Marie Curie-Paris 6, 4 place Jussieu, 75005, Paris, France aut NATIONALLICENCE 700 1- Lin Ruichao Biomedicine Key Laboratory of Shaanxi Province, The College of Life Sciences, Northwest University, No.229 Taibai North Road, 710069, Xi'an, Shaanxi, China aut NATIONALLICENCE 700 1- Sun Wenji Biomedicine Key Laboratory of Shaanxi Province, The College of Life Sciences, Northwest University, No.229 Taibai North Road, 710069, Xi'an, Shaanxi, China aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73/5-6(2011-03-01), 599-603 0009-5893 73:5-6<599 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer