caa a22 4500 445802421 CHVBK 20180317145145.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10337-010-1831-3 doi (NATIONALLICENCE)springer-10.1007/s10337-010-1831-3 Quantitative Structure-Retention Relationship Study of Some 5-Substituted-5-Phenylhydantoins [Elektronische Daten] [Tatjana Djaković-Sekulić, Zagorka Lozanov-Crvenković, Anamarija Mandić, Gordana Uščumlić, Svetlana Keleman] In this study 18 hydantoin derivatives were investigated by means of reversed-phase LC on C-18 stationary phase and methanol-water eluent. Quantitative structure-retention relationship study has been applied in order to understand factors that affect the chromatographic behavior which is closely correlated to the activity (ED50 values). A multiple linear regression procedure was used to model the relationships between molecular descriptors and retention of the hydantoin derivatives. The best quantitative structure-activity relationship (QSAR) models were further validated by a leave-one-out technique as well as by the calculation of statistical parameters for the established theoretical models. High agreement between experimental and predicted data obtained in the validation procedure indicated good quality of the derived QSAR models. Springer-Verlag, 2011 Quantitative structure-retention relationship nationallicence Multiple linear regression nationallicence Molecular descriptors nationallicence Anticonvulsants nationallicence 5,5-Disubstitutedhydantoins nationallicence Djaković-Sekulić Tatjana Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad Faculty of Sciences, Trg Dositeja Obradovića 3, 21000, Novi Sad, Republic of Serbia aut Lozanov-Crvenković Zagorka Department of Mathematics and Informatics, University of Novi Sad Faculty of Sciences, Trg Dositeja Obradovića 4, 21000, Novi Sad, Republic of Serbia aut Mandić Anamarija Institute for Food Technology, Bulevar Cara Lazara 1, 21000, Novi Sad, Republic of Serbia aut Uščumlić Gordana Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, PO Box 3503, 11120, Belgrade, Republic of Serbia aut Keleman Svetlana Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad Faculty of Sciences, Trg Dositeja Obradovića 3, 21000, Novi Sad, Republic of Serbia aut Chromatographia Vieweg Verlag 73/1-2(2011-01-01), 51-57 0009-5893 73:1-2<51 2011 73 10337 https://doi.org/10.1007/s10337-010-1831-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-010-1831-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Djaković-Sekulić Tatjana Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad Faculty of Sciences, Trg Dositeja Obradovića 3, 21000, Novi Sad, Republic of Serbia aut NATIONALLICENCE 700 1- Lozanov-Crvenković Zagorka Department of Mathematics and Informatics, University of Novi Sad Faculty of Sciences, Trg Dositeja Obradovića 4, 21000, Novi Sad, Republic of Serbia aut NATIONALLICENCE 700 1- Mandić Anamarija Institute for Food Technology, Bulevar Cara Lazara 1, 21000, Novi Sad, Republic of Serbia aut NATIONALLICENCE 700 1- Uščumlić Gordana Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, PO Box 3503, 11120, Belgrade, Republic of Serbia aut NATIONALLICENCE 700 1- Keleman Svetlana Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad Faculty of Sciences, Trg Dositeja Obradovića 3, 21000, Novi Sad, Republic of Serbia aut NATIONALLICENCE 773 0- Chromatographia Vieweg Verlag 73/1-2(2011-01-01), 51-57 0009-5893 73:1-2<51 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer