caa a22 4500 445802448 CHVBK 20180317145145.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10337-011-1912-y doi (NATIONALLICENCE)springer-10.1007/s10337-011-1912-y Simultaneous Determination of Strychnine, Brucine, Strychnine N -Oxide and Brucine N -Oxide in Crude and Fermented Nux Vomica by CZE with Ephedrine Hydrochloride as an Internal Standard [Elektronische Daten] [Guangming Yang, Yang Pan, Liangjing Liu, Yaping Jiang] A rapid capillary zone electrophoresis (CZE) method with ephedrine hydrochloride as an internal standard was developed and validated for separating and quantifying the alkaloids strychnine (1), brucine (2), strychnine N-oxide (3), and brucine N-oxide (4) in the seed of Strychnos nux-vomica L. (crude nux vomica) and its fermented products by fungus Trametes cinnabarina (Jacq.: Fr.) Fr. (fermented nux vomica). The contents of alkaloids (1 and 2) in crude nux vomica were higher than those in fermented drugs, whereas alkaloids (3 and 4) were only detected in fermented ones. The method developed is sensitive, specific and accurate, as well as effective and easy, which can be used to assess the qualities of crude and fermented nux vomica. Springer-Verlag, 2011 Capillary zone electrophoresis nationallicence Strychnine and strychnine N -oxide nationallicence Brucine and brucine N -oxide nationallicence Ephedrine hydrochloride nationallicence Crude and fermented nux vomica nationallicence Yang Guangming Jiangsu Key Laboratory of Chinese Medicine Processing Nanjing, University of Chinese Medicine, 210029, Nanjing, China aut Pan Yang Laboratory of Medical Fungi and Phyto-Biotech Nanjing, University of Chinese Medicine, 210029, Nanjing, China aut Liu Liangjing Laboratory of Medical Fungi and Phyto-Biotech Nanjing, University of Chinese Medicine, 210029, Nanjing, China aut Jiang Yaping Laboratory of Medical Fungi and Phyto-Biotech Nanjing, University of Chinese Medicine, 210029, Nanjing, China aut Chromatographia Springer-Verlag 73/11-12(2011-06-01), 1223-1228 0009-5893 73:11-12<1223 2011 73 10337 https://doi.org/10.1007/s10337-011-1912-y text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-1912-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Guangming Jiangsu Key Laboratory of Chinese Medicine Processing Nanjing, University of Chinese Medicine, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Pan Yang Laboratory of Medical Fungi and Phyto-Biotech Nanjing, University of Chinese Medicine, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Liu Liangjing Laboratory of Medical Fungi and Phyto-Biotech Nanjing, University of Chinese Medicine, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Jiang Yaping Laboratory of Medical Fungi and Phyto-Biotech Nanjing, University of Chinese Medicine, 210029, Nanjing, China aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73/11-12(2011-06-01), 1223-1228 0009-5893 73:11-12<1223 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer