caa a22 4500 445802693 CHVBK 20180317145146.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10337-011-2013-7 doi (NATIONALLICENCE)springer-10.1007/s10337-011-2013-7 Determination of p K a Values of Cefdinir and Cefixime by LC and Spectrophotometric Methods and Their Analysis in Pharmaceutical Dosage Forms [Elektronische Daten] [Nurullah Sanli, Senem Sanli, Umit Sızır, Mehmet Gumustas, Sibel Ozkan] The pK a values of cefdinir and cefixime, which are used in the treatment of bacterial infections, have been determined precisely in water and methanol-water binary mixtures (20% v/v) using spectrophotometric titration and LC, respectively. A simple, fast and precise isocratic high-performance liquid chromatographic (LC) procedure has been developed for the determination of cefdinir and cefixime in drug formulations. This method was validated successfully for specificity, precision, linearity, range, accuracy, limit of detection, and limit of quantitation as per the ICH guidelines. The proposed method can be used for routine analysis of studied cephalosporin compounds and as an alternative tool for drug quality control laboratories. Springer-Verlag, 2011 Column liquid chromatograph nationallicence Cefdinir nationallicence Cefixime nationallicence Dissociation constants nationallicence Sanli Nurullah Department of Chemistry, Faculty of Science and Arts, Hitit University, Çorum, Turkey aut Sanli Senem Department of Chemistry, Faculty of Science and Arts, Hitit University, Çorum, Turkey aut Sızır Umit Department of Chemistry, Faculty of Science and Arts, Hitit University, Çorum, Turkey aut Gumustas Mehmet Department of Chemistry, Faculty of Science and Arts, Hitit University, Çorum, Turkey aut Ozkan Sibel Faculty of Pharmacy, Department of Analytical Chemistry, Ankara University, Tandogan, Ankara, Turkey aut Chromatographia Springer-Verlag 73/11-12(2011-06-01), 1171-1176 0009-5893 73:11-12<1171 2011 73 10337 https://doi.org/10.1007/s10337-011-2013-7 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-2013-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sanli Nurullah Department of Chemistry, Faculty of Science and Arts, Hitit University, Çorum, Turkey aut NATIONALLICENCE 700 1- Sanli Senem Department of Chemistry, Faculty of Science and Arts, Hitit University, Çorum, Turkey aut NATIONALLICENCE 700 1- Sızır Umit Department of Chemistry, Faculty of Science and Arts, Hitit University, Çorum, Turkey aut NATIONALLICENCE 700 1- Gumustas Mehmet Department of Chemistry, Faculty of Science and Arts, Hitit University, Çorum, Turkey aut NATIONALLICENCE 700 1- Ozkan Sibel Faculty of Pharmacy, Department of Analytical Chemistry, Ankara University, Tandogan, Ankara, Turkey aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73/11-12(2011-06-01), 1171-1176 0009-5893 73:11-12<1171 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer