caa a22 4500 445802731 CHVBK 20180317145146.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10337-010-1897-y doi (NATIONALLICENCE)springer-10.1007/s10337-010-1897-y Enantioseparation of the New Antifungal Drug Iodiconazole and Structurally Related Triadimenol Analogues by CE with Neutral Cyclodextrin Additives [Elektronische Daten] [Wuhong Li, Liang Zhao, Guangguo Tan, Chunquan Sheng, Xinrong Zhang, Zhenyu Zhu, Guoqing Zhang, Yifeng Chai] Chiral separation of iodiconazole, a new antifungal drug, and 12 new structurally related triadimenol analogues were studied by capillary electrophoresis with seven neutral cyclodextrins. It was found that hydroxypropyl-γ-cyclodextrin (HP-γ-CD) was the most effective chiral selector. Furthermore, the influence of the concentration of HP-γ-CD, buffer pH, buffer concentration, temperature, and applied voltage was investigated, and the method was validated. The study of the analyte structure-enantioseparation relationships showed that substitutions in the side chains had important influences on enantiomeric separation. Springer-Verlag, 2011 Capillary electrophoresis nationallicence Enantioseparation nationallicence Hydroxypropyl- γ -cyclodextrin nationallicence Iodiconazole nationallicence Triadimenol analogue nationallicence Li Wuhong School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Zhao Liang Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200433, Shanghai, China aut Tan Guangguo School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Sheng Chunquan School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Zhang Xinrong School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Zhu Zhenyu School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Zhang Guoqing Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200433, Shanghai, China aut Chai Yifeng School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Chromatographia Springer-Verlag 73/9-10(2011-05-01), 1009-1014 0009-5893 73:9-10<1009 2011 73 10337 https://doi.org/10.1007/s10337-010-1897-y text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-010-1897-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Wuhong School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Zhao Liang Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Tan Guangguo School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Sheng Chunquan School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Zhang Xinrong School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Zhu Zhenyu School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Zhang Guoqing Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Chai Yifeng School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73/9-10(2011-05-01), 1009-1014 0009-5893 73:9-10<1009 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer