caa a22 4500 445802782 CHVBK 20180317145146.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10337-011-1979-5 doi (NATIONALLICENCE)springer-10.1007/s10337-011-1979-5 Use of HPLC in the Determination of the Molar Absorptivity of 4′-Geranyloxyferulic Acid and Boropinic Acid [Elektronische Daten] [Marcello Locatelli, Giuseppe Carlucci, Salvatore Genovese, Massimo Curini, Francesco Epifano] Natural prenyloxycinnamic acids were shown to exert in vitro and in vivo remarkable and valuable anti-cancer and anti-inflammatory effects. Among these, 4′-geranyloxyferulic acid [3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid] was discovered as an efficient orally active chemopreventive agent of several types of cancer, and its structural analogue boropinic acid was shown to exert a valuable inhibitory effect both in vitro and in vivo against the growth of Helicobacter pylori. As a continuation of our chemical, chemico-physical, and pharmacological studies on these secondary metabolites, we report herein the comparison between traditional UV/Vis assays and HPLC-DAD methods for the determination of the molar absorptivity coefficient of 4′-geranyloxyferulic acid (ε 310=12,950 and ε 288=11,910L mol−1cm−1) and boropinic acid (ε 310=13,510 and ε 288=12,350L mol−1cm−1). Ferulic acid was merely used as a reference standard to test the possibility of the application of these two assays to the oxyprenylated compounds. The data reported in the present study will represent an essential aid for future studies aimed to better define the pharmacological profile and the mechanism of action of these compounds and are an important starting point to evaluate other natural products where standard powders are not available. Springer-Verlag, 2011 Column liquid chromatography nationallicence Molar absorptivity coefficient nationallicence 3-(4′-Geranyloxy-3′-methoxyphenyl)-2- trans -propenoic acid nationallicence Boropinic acid nationallicence Prenyloxyphenylpropanoids nationallicence HPLC-DAD method nationallicence GOFA : 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid nationallicence Locatelli Marcello Dipartimento di Scienze del Farmaco, Università degli Studi "G. D'Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100, Chieti (CH), Italy aut Carlucci Giuseppe Dipartimento di Scienze del Farmaco, Università degli Studi "G. D'Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100, Chieti (CH), Italy aut Genovese Salvatore Dipartimento di Scienze del Farmaco, Università degli Studi "G. D'Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100, Chieti (CH), Italy aut Curini Massimo Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Università degli Studi di Perugia, Via del Liceo, 06123, Perugia (PG), Italy aut Epifano Francesco Dipartimento di Scienze del Farmaco, Università degli Studi "G. D'Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100, Chieti (CH), Italy aut Chromatographia Springer-Verlag 73/9-10(2011-05-01), 889-896 0009-5893 73:9-10<889 2011 73 10337 https://doi.org/10.1007/s10337-011-1979-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-1979-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Locatelli Marcello Dipartimento di Scienze del Farmaco, Università degli Studi "G. D'Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100, Chieti (CH), Italy aut NATIONALLICENCE 700 1- Carlucci Giuseppe Dipartimento di Scienze del Farmaco, Università degli Studi "G. D'Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100, Chieti (CH), Italy aut NATIONALLICENCE 700 1- Genovese Salvatore Dipartimento di Scienze del Farmaco, Università degli Studi "G. D'Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100, Chieti (CH), Italy aut NATIONALLICENCE 700 1- Curini Massimo Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Università degli Studi di Perugia, Via del Liceo, 06123, Perugia (PG), Italy aut NATIONALLICENCE 700 1- Epifano Francesco Dipartimento di Scienze del Farmaco, Università degli Studi "G. D'Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100, Chieti (CH), Italy aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73/9-10(2011-05-01), 889-896 0009-5893 73:9-10<889 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer