caa a22 4500 445802871 CHVBK 20180317145147.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10337-011-1965-y doi (NATIONALLICENCE)springer-10.1007/s10337-011-1965-y Extraction and Separation Properties of Hydrophilic Compounds Using Novel Water-Holding Adsorbents Bonded with a Zwitter-Ionic Polymer [Elektronische Daten] [Yoshinori Inoue, Waka Kamichatani, Mitsuru Saito, Yasuyuki Kobayashi, Atsushi Yamamoto] A novel water-holding adsorbent was synthesized by introducing a zwitter-ionic polymer to a hydrophilic methacrylate base resin. The retention abilities of the hydrophilic compounds on the adsorbents with and without cross-link in the zwitter-ionic functional groups were examined. The amount of held water on the non-cross-linked adsorbent was higher than that of the cross-linked one. The extraction efficiencies of the hydrophilic solutes on the adsorbents were evaluated by the solid phase extraction method. These adsorbents showed high affinity for nucleosides and glycosides, and good recoveries for such hydrophilic compounds in the solid-phase extraction were obtained. Furthermore, the retention properties of the hydrophilic solutes on the adsorbents were also evaluated by LC. The hydrophilic solutes were retained on these adsorbents by a partition mode based on a hydrophilic interaction. The retention factors of the hydrophilic solutes showed good correlation to their logP o/w (logarithm of octanol-water partition coefficient) and good separation based on hydrophilic interaction was obtained for nucleobases and nucleosides. Springer-Verlag, 2011 Column liquid chromatography nationallicence Solid phase extraction nationallicence Hydrophilic interaction nationallicence Weak zwitter-ionic functional group nationallicence Water-holding adsorbent nationallicence Inoue Yoshinori Products Planning & Development Department, R&D Center, Nippon Filcon Co., Ltd., 2220 Ohmaru, 206-8577, Inagi-shi, Tokyo, Japan aut Kamichatani Waka Products Planning & Development Department, R&D Center, Nippon Filcon Co., Ltd., 2220 Ohmaru, 206-8577, Inagi-shi, Tokyo, Japan aut Saito Mitsuru Products Planning & Development Department, R&D Center, Nippon Filcon Co., Ltd., 2220 Ohmaru, 206-8577, Inagi-shi, Tokyo, Japan aut Kobayashi Yasuyuki College of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, 487-8501, Kasugai-shi, Aichi, Japan aut Yamamoto Atsushi College of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, 487-8501, Kasugai-shi, Aichi, Japan aut Chromatographia Springer-Verlag 73/9-10(2011-05-01), 849-855 0009-5893 73:9-10<849 2011 73 10337 https://doi.org/10.1007/s10337-011-1965-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-1965-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inoue Yoshinori Products Planning & Development Department, R&D Center, Nippon Filcon Co., Ltd., 2220 Ohmaru, 206-8577, Inagi-shi, Tokyo, Japan aut NATIONALLICENCE 700 1- Kamichatani Waka Products Planning & Development Department, R&D Center, Nippon Filcon Co., Ltd., 2220 Ohmaru, 206-8577, Inagi-shi, Tokyo, Japan aut NATIONALLICENCE 700 1- Saito Mitsuru Products Planning & Development Department, R&D Center, Nippon Filcon Co., Ltd., 2220 Ohmaru, 206-8577, Inagi-shi, Tokyo, Japan aut NATIONALLICENCE 700 1- Kobayashi Yasuyuki College of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, 487-8501, Kasugai-shi, Aichi, Japan aut NATIONALLICENCE 700 1- Yamamoto Atsushi College of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, 487-8501, Kasugai-shi, Aichi, Japan aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73/9-10(2011-05-01), 849-855 0009-5893 73:9-10<849 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer