caa a22 4500 445802944 CHVBK 20180317145147.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10337-011-1980-z doi (NATIONALLICENCE)springer-10.1007/s10337-011-1980-z Evaluation of Generic Gradients, Sample Pooling and MS Detection as Chiral Resolution Screening Strategies on Diverse Chiral Stationary Phases [Elektronische Daten] [Mahesh Mone, K. Chandrasekhar] Increased throughput in medicinal chemistry has substantially increased the production of new chiral chemical entities with diverse structural features, requiring fast chiral screening strategies. In an effort to explore screening methods we have developed and evaluated gradients in polar organic and normal phase modes on three popular chiral stationary phases using a sample set of 19 racemic compounds. When compared, gradients performed on par with the isocratic methods besides proving to be advantageous in terms of speed of analysis and elution capacity. MS detection was successfully applied to the analysis of a pooled sample consisting 19 compounds to speed-up the screening process. Springer-Verlag, 2011 Column liquid chromatography-mass spectrometry nationallicence Chiral screening nationallicence Sample pooling nationallicence Normal phase gradients nationallicence Drug discovery nationallicence Mone Mahesh Drug Discovery Facility, Advinus Therapeutics, Quantum Towers, Plot-9, Rajiv Gandhi Infotech Park, Phase-I Hinjewadi, 411 057, Pune, India aut Chandrasekhar K. Department of Chemistry, Jawaharlal Nehru Technological University, College of Engineering, 515 002, Anantapur, India aut Chromatographia Springer-Verlag 73/9-10(2011-05-01), 985-992 0009-5893 73:9-10<985 2011 73 10337 https://doi.org/10.1007/s10337-011-1980-z text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-1980-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mone Mahesh Drug Discovery Facility, Advinus Therapeutics, Quantum Towers, Plot-9, Rajiv Gandhi Infotech Park, Phase-I Hinjewadi, 411 057, Pune, India aut NATIONALLICENCE 700 1- Chandrasekhar K. Department of Chemistry, Jawaharlal Nehru Technological University, College of Engineering, 515 002, Anantapur, India aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 73/9-10(2011-05-01), 985-992 0009-5893 73:9-10<985 2011 73 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer