caa a22 4500 445803096 CHVBK 20180317145147.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10337-011-2049-8 doi (NATIONALLICENCE)springer-10.1007/s10337-011-2049-8 Analysis of Fluoroquinolones in Animal Feed Based on Microwave-Assisted Extraction by LC-MS-MS Determination [Elektronische Daten] [Haoyan Xu, Tianyi Wang, Qi Zhao, Qinglei Zeng, Hui Wang, Yang Xu, Xiaopan Zhang, Feng Wang, Lan Ding] An environmentally friendly method for the determination of fluoroquinolone (FQ) antibiotics including enrofloxacin, ciprofloxacin, levofloxacin, fleroxacin and sparfloxacin in four feeds is proposed. Disodium ethylenediaminetetraacetate (EDTA)-Mcllvaine buffer (0.1molL−1, pH4.0) was used as an extracting solvent and the extraction process was accelerated by microwave irradiation. No organic solvents were used in the extraction procedure. The extract obtained was then cleaned up and concentrated by an Oasis hydrophilic-lipophilic balance (HLB) solid-phase extraction cartridge. The relative intra- and inter-day standard deviations obtained were in the range of 3.7-9.1 and 2.1-11.4%, respectively. In the three fortified levels of blank feed sample (30, 100 and 500ngg−1), recoveries of FQs ranging from 61.1 to 97.9% were obtained. The analytes desorbed from HLB were analyzed by liquid chromatography-tandem mass spectrometry. The limit of detection was in the range of 5.0-9.1ngg−1. The method presented here can be considered a promising alternative to traditional techniques using shaking or stirring for extraction, being more effective, and producing less pollution. Springer-Verlag, 2011 Column liquid chromatography-tandem mass spectrometry nationallicence Microwave-assisted extraction nationallicence Fluoroquinolones nationallicence Animal feed nationallicence Xu Haoyan College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut Wang Tianyi College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut Zhao Qi College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut Zeng Qinglei College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut Wang Hui College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut Xu Yang College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut Zhang Xiaopan College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut Wang Feng Department of Justice, Guannan County, 222500, Guannan, Jiangsu, China aut Ding Lan College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut Chromatographia Springer-Verlag 74/3-4(2011-08-01), 267-274 0009-5893 74:3-4<267 2011 74 10337 https://doi.org/10.1007/s10337-011-2049-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-2049-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xu Haoyan College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut NATIONALLICENCE 700 1- Wang Tianyi College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut NATIONALLICENCE 700 1- Zhao Qi College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut NATIONALLICENCE 700 1- Zeng Qinglei College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut NATIONALLICENCE 700 1- Wang Hui College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut NATIONALLICENCE 700 1- Xu Yang College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut NATIONALLICENCE 700 1- Zhang Xiaopan College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut NATIONALLICENCE 700 1- Wang Feng Department of Justice, Guannan County, 222500, Guannan, Jiangsu, China aut NATIONALLICENCE 700 1- Ding Lan College of Chemistry, Jilin University, 2699 Qianjin Street, 130012, Changchun, China aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 74/3-4(2011-08-01), 267-274 0009-5893 74:3-4<267 2011 74 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer