caa a22 4500 445803142 CHVBK 20180317145147.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10337-011-2052-0 doi (NATIONALLICENCE)springer-10.1007/s10337-011-2052-0 Quantification of Tricyclic and Nontricyclic Antidepressants in Spiked Plasma and Urine Samples Using Microextraction in Packed Syringe and Analysis by LC and GC-MS [Elektronische Daten] [Susheela Rani, Ashwini Kumar, Ashok Malik, Baldev Singh] A simple, fast, selective and very sensitive method based on sample preparation by the relatively new technique of microextraction in a packed syringe (MEPS) and analysis by liquid chromatography (LC) and gas chromatography-mass spectrometry (GC-MS) for the simultaneous determination of antidepressant drugs (amitriptyline, imipramine, clomipramine, mirtazapine and citalopram) was developed. MEPS is a new miniaturized, solid-phase extraction (SPE) technique that can be connected to LC or GC without any modifications. It is very easy to use, fully automated, inexpensive, quick and uses very small amounts (in μL) of organic solvents. Drugs are extracted using the MEPS technique followed by their analysis using LC-UV and GC-MS. Limits of detection were in the range of 0.088-0.284ngmL−1 on GC-MS and between 0.133 and 0.360ngmL−1 on LC-UV. The purpose of this study is to develop and validate MEPS as a new sample preparation technique for antidepressant drugs using chromatographic methods to detect these drugs in human plasma and urine samples. Springer-Verlag, 2011 HPLC nationallicence Gas chromatography-mass spectrometry nationallicence Microextraction in packed syringes nationallicence Antidepressants nationallicence Rani Susheela Department of Chemistry, Punjabi University, 147002, Patiala, India aut Kumar Ashwini Department of Chemistry, Punjabi University, 147002, Patiala, India aut Malik Ashok Department of Chemistry, Punjabi University, 147002, Patiala, India aut Singh Baldev Department of Chemistry, Punjabi University, 147002, Patiala, India aut Chromatographia Springer-Verlag 74/3-4(2011-08-01), 235-242 0009-5893 74:3-4<235 2011 74 10337 https://doi.org/10.1007/s10337-011-2052-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-2052-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rani Susheela Department of Chemistry, Punjabi University, 147002, Patiala, India aut NATIONALLICENCE 700 1- Kumar Ashwini Department of Chemistry, Punjabi University, 147002, Patiala, India aut NATIONALLICENCE 700 1- Malik Ashok Department of Chemistry, Punjabi University, 147002, Patiala, India aut NATIONALLICENCE 700 1- Singh Baldev Department of Chemistry, Punjabi University, 147002, Patiala, India aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 74/3-4(2011-08-01), 235-242 0009-5893 74:3-4<235 2011 74 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer