caa a22 4500 445803185 CHVBK 20180317145148.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10337-011-2072-9 doi (NATIONALLICENCE)springer-10.1007/s10337-011-2072-9 Urinary Metabolites of Isoliquiritigenin in Wistar Rats using UHPLC-TOF-MS-based Xenometabolomics [Elektronische Daten] [Guangguo Tan, Ziyang Lou, Xing Dong, Wuhong Li, Wenting Liao, Zhenyu Zhu, Yifeng Chai] Isoliquiritigenin, a chalcone found in licorice root and many other plants, has shown potential antioxidant, estrogenic and antitumor activities. The present study was to investigate urinary metabolism of isoliquiritigenin in Wistar rats by ultra-high pressure liquid chromatography coupled to electrospray ionization TOF-MS (UHPLC-TOF-MS)-based xenometabolomics. Urine samples were collected before and after oral administration of isoliquiritigenin, and analyzed by UHPLC-TOF-MS. After deconvolution, the resulting data matrices were subjected to multivariate data analysis. Projection to latent structures discriminant analysis was performed to screen the metabolites. Fifteen urinary metabolites of isoliquiritigenin were screened out and 13 of them were further identified by Agilent MassHunter Software. The results of this work show that UHPLC-TOF-MS-based xenometabolomics was able to comprehensively identify the metabolites of phytochemicals and may represent a valuable tool for monitoring the food consumption. Springer-Verlag, 2011 UHPLC-TOF-MS nationallicence Isoliquiritigenin nationallicence Xenometabolomics nationallicence Urinary metabolites nationallicence Rat nationallicence Tan Guangguo School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Lou Ziyang School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Dong Xing School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Li Wuhong School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Liao Wenting School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Zhu Zhenyu School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Chai Yifeng School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut Chromatographia Springer-Verlag 74/3-4(2011-08-01), 341-348 0009-5893 74:3-4<341 2011 74 10337 https://doi.org/10.1007/s10337-011-2072-9 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-2072-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tan Guangguo School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Lou Ziyang School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Dong Xing School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Li Wuhong School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Liao Wenting School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Zhu Zhenyu School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 700 1- Chai Yifeng School of Pharmacy, Second Military Medical University, 200433, Shanghai, China aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 74/3-4(2011-08-01), 341-348 0009-5893 74:3-4<341 2011 74 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer