caa a22 4500 445803703 CHVBK 20180317145150.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10337-011-2047-x doi (NATIONALLICENCE)springer-10.1007/s10337-011-2047-x Preparation and Evaluation of Long Chain Alkyl Methacrylate Monoliths for Capillary Chromatography [Elektronische Daten] [Zeid ALOthman, Ahmad Aqel, Hadeel Al Abdelmoneim, A. Yacine Badjah-Hadj-Ahmed, Abdulrahman Al-Warthan] This work describes the fabrication of long chain alkyl methacrylate monolithic materials for use as stationary phases in capillary liquid chromatography. After capillary inner wall surface activation with 3-(trimethoxysilyl)propyl methacrylate, monoliths were formed by copolymerization of either lauryl or stearyl methacrylate (LMA or SMA) with ethylene dimethacrylate (EDMA) as crosslinker, in the presence of azobisisobutyronitrile (AIBN) as initiator and a mixture of porogenic solvents including water, 1-propanol and 1,4-butanediol. The composition of the polymerization mixture was changed in terms of monomer, crosslinker and porogen ratio composition, in order to compare the influence of these parameters. The monoliths were prepared in 320μm i.d. and 200mm length capillaries. The column morphology was characterized by optical microscopy and scanning electron microscopy (SEM). Total porosity and permeability of each column were calculated using uracil as unretained material by measuring the pressure drop across the columns as a function of linear velocity. The microglobule average size for each column was also determined using Hagen-Poiseuille equation and compared with the SEM images. As expected, a decrease of the porogen to monomer ratio corresponded to smaller microglobules and a lower total porosity. The columns were then chromatographically evaluated; good results were obtained when these capillaries were used to separate mixtures of phenols, aromatics and drug compounds. Springer-Verlag, 2011 Capillary liquid chromatography nationallicence Monolithic column nationallicence Lauryl methacrylate nationallicence Stearyl methacrylate nationallicence Ethylene dimethacrylate nationallicence ALOthman Zeid Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Kingdom of Saudi Arabia aut Aqel Ahmad King Abdullah Institute for Nanotechnology, College of Science, King Saud University, P.O. Box 2454, 11451, Riyadh, Kingdom of Saudi Arabia aut Al Abdelmoneim Hadeel Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Kingdom of Saudi Arabia aut Yacine Badjah-Hadj-Ahmed A. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Kingdom of Saudi Arabia aut Al-Warthan Abdulrahman King Abdullah Institute for Nanotechnology, College of Science, King Saud University, P.O. Box 2454, 11451, Riyadh, Kingdom of Saudi Arabia aut Chromatographia Springer-Verlag 74/1-2(2011-07-01), 1-8 0009-5893 74:1-2<1 2011 74 10337 https://doi.org/10.1007/s10337-011-2047-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-2047-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- ALOthman Zeid Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Kingdom of Saudi Arabia aut NATIONALLICENCE 700 1- Aqel Ahmad King Abdullah Institute for Nanotechnology, College of Science, King Saud University, P.O. Box 2454, 11451, Riyadh, Kingdom of Saudi Arabia aut NATIONALLICENCE 700 1- Al Abdelmoneim Hadeel Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Kingdom of Saudi Arabia aut NATIONALLICENCE 700 1- Yacine Badjah-Hadj-Ahmed A. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Kingdom of Saudi Arabia aut NATIONALLICENCE 700 1- Al-Warthan Abdulrahman King Abdullah Institute for Nanotechnology, College of Science, King Saud University, P.O. Box 2454, 11451, Riyadh, Kingdom of Saudi Arabia aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 74/1-2(2011-07-01), 1-8 0009-5893 74:1-2<1 2011 74 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer