caa a22 4500 445803967 CHVBK 20180317145151.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10337-011-2138-8 doi (NATIONALLICENCE)springer-10.1007/s10337-011-2138-8 Investigation of Enantiomeric Separation of Chiral Drugs by CE Using Cu(II)-Clindamycin Complex as a Novel Chiral Selector [Elektronische Daten] [Jianfeng Wu, Peng Liu, Qingwei Wang, Hui Chen, Peng Gao, Li Wang, Shengyong Zhang] The enantiomeric separation of several basic drugs was investigated using copper(II)-clindamycin as a new chiral selector. The results show that the chiral selector allows high-resolution separation of some racemic basic drugs, including tropicamide, propranolol, sotalol, bisoprolol, epinephrine, esmolol, atenolol, and metoprolol. The enantioselectivity was influenced by parameters such as the type of metal ion, ratio of clindamycin and Cu(II), pH of the background electrolyte, clindamycin concentration, applied voltage, and capillary temperature. The optimal separation conditions were determined to be 20mM clindamycin/10mM Cu2+, pH 9.06, at 20kV and 22°C within 25min. Springer-Verlag, 2011 Capillary electrophoresis nationallicence Cu(II)-clindamycin complexes nationallicence Chiral selector nationallicence Enantiomeric separation nationallicence Wu Jianfeng Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut Liu Peng Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut Wang Qingwei Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut Chen Hui Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut Gao Peng Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut Wang Li Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut Zhang Shengyong Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut Chromatographia Springer-Verlag 74/11-12(2011-12-01), 789-797 0009-5893 74:11-12<789 2011 74 10337 https://doi.org/10.1007/s10337-011-2138-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-2138-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu Jianfeng Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut NATIONALLICENCE 700 1- Liu Peng Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut NATIONALLICENCE 700 1- Wang Qingwei Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut NATIONALLICENCE 700 1- Chen Hui Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut NATIONALLICENCE 700 1- Gao Peng Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut NATIONALLICENCE 700 1- Wang Li Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut NATIONALLICENCE 700 1- Zhang Shengyong Research Center for Chirotechnology, Fourth Military Medical University, 710032, Xi'an, China aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 74/11-12(2011-12-01), 789-797 0009-5893 74:11-12<789 2011 74 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer