caa a22 4500 445804149 CHVBK 20180317145151.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10337-011-2131-2 doi (NATIONALLICENCE)springer-10.1007/s10337-011-2131-2 A Validated LC Method for Determination of Trace Impurities in Technical Triadimefon [Elektronische Daten] [Meng-xiang Su, Lin-jun You, Bin Di, Lan-jin Qu, Tai-jun Hang] A simple and sensitive liquid chromatography with ultraviolet detection (LC-UV) method was developed for the determination of three impurities with a content over 0.1% (w/w) in technical triadimefon. A Gemini C18 column (5μm, 250mm×4.6mm i.d.) was used for the chromatographic separations. The samples were separated by gradient elution with water (solvent A) and methanol (solvent B) using the following conditions: 70% A isocratic for 12min, linear to 0% A within 8min, and isocratic for 10min at 0% A with a flow rate of 1.0mLmin−1. Chromatograms were recorded at an absorption wavelength of 280nm. The chromatographic resolutions between triadimefon and its potential impurities A, B, and C were greater than 3. The developed LC method was validated with respect to linearity, accuracy, precision, and robustness. This method was successfully applied to analyze the impurities in commercial technical triadimefon. In addition, the structures of the three impurities were identified to be (A) 4-chlorophenol, (B) 1-(2,4-dichlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone, and (C) 1,1-bis(4-chlorophenoxy)-3,3-dimethyl-2-butanone. Springer-Verlag, 2011 Column liquid chromatography nationallicence Determination nationallicence Impurity nationallicence Triadimefon nationallicence Su Meng-xiang Department of Pharmaceutical Analysis, China Pharmaceutical University, 210009, Nanjing, China aut You Lin-jun Department of Pharmaceutical Analysis, China Pharmaceutical University, 210009, Nanjing, China aut Di Bin Department of Pharmaceutical Analysis, China Pharmaceutical University, 210009, Nanjing, China aut Qu Lan-jin Department of Pharmaceutical Analysis, China Pharmaceutical University, 210009, Nanjing, China aut Hang Tai-jun Department of Pharmaceutical Analysis, China Pharmaceutical University, 210009, Nanjing, China aut Chromatographia Springer-Verlag 74/9-10(2011-11-01), 737-741 0009-5893 74:9-10<737 2011 74 10337 https://doi.org/10.1007/s10337-011-2131-2 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10337-011-2131-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Su Meng-xiang Department of Pharmaceutical Analysis, China Pharmaceutical University, 210009, Nanjing, China aut NATIONALLICENCE 700 1- You Lin-jun Department of Pharmaceutical Analysis, China Pharmaceutical University, 210009, Nanjing, China aut NATIONALLICENCE 700 1- Di Bin Department of Pharmaceutical Analysis, China Pharmaceutical University, 210009, Nanjing, China aut NATIONALLICENCE 700 1- Qu Lan-jin Department of Pharmaceutical Analysis, China Pharmaceutical University, 210009, Nanjing, China aut NATIONALLICENCE 700 1- Hang Tai-jun Department of Pharmaceutical Analysis, China Pharmaceutical University, 210009, Nanjing, China aut NATIONALLICENCE 773 0- Chromatographia Springer-Verlag 74/9-10(2011-11-01), 737-741 0009-5893 74:9-10<737 2011 74 10337 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer