caa a22 4500 445807067 CHVBK 20180317145159.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00415-010-5666-5 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5666-5 Preserved serotonin transporter binding in de novo Parkinson's disease: negative correlation with the dopamine transporter [Elektronische Daten] [Karl Strecker, Florian Wegner, Swen Hesse, Georg-Alexander Becker, Marianne Patt, Philipp Meyer, Donald Lobsien, Johannes Schwarz, Osama Sabri] Recent imaging and neuropathological studies indicate reduced serotonin transporter (SERT) in advanced Parkinson's disease (PD). However, data on SERT in early PD patients are sparse. Following the hypothesis that the serotonergic system is damaged early in PD, the aim of our study was to investigate SERT availability by means of PET imaging. Since the loss of dopaminergic neurons is the pathologic hallmark of PD and SERT might be associated with psychiatric co-morbidity, we further sought to correlate SERT availability with the availability of dopamine transporter (DAT) and depressive or motor symptoms in early PD. We prospectively recruited nine early PD patients (4 female, 5 male; 42-76 years) and nine age matched healthy volunteers (5 female, 4 male; 42-72 years). Diagnosis of PD was confirmed by the UK brain bank criteria and DAT imaging. SERT availability was measured by means of [11C]DASB PET. For neuropsychiatric assessment done on the day of PET we applied UPDRS parts I, II and III, Beck's Depression Inventory, Hamilton Rating Scale for Depression, Mini-Mental State Examination and Demtect. SERT was not reduced in any of 14 investigated regions of interest in the nine PD patients compared to healthy controls (p>0.13). SERT was negatively associated with DAT in the striatum (r=−0.69; p=0.04) but not within the midbrain. There was no correlation of SERT availability with depressive symptoms. No alteration of SERT binding in our patients suggests that the serotonergic system is remarkably preserved in early PD. Correlation with DAT might point to a compensatory regulation of the serotonergic system in early stages of PD. Springer-Verlag, 2010 Parkinson's disease nationallicence Serotonin transporter nationallicence Positron emission tomography nationallicence PET nationallicence Dopamine transporter nationallicence Strecker Karl Department of Neurology, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany aut Wegner Florian Department of Neurology, Medical School Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut Hesse Swen Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103, Leipzig, Germany aut Becker Georg-Alexander Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103, Leipzig, Germany aut Patt Marianne Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103, Leipzig, Germany aut Meyer Philipp Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103, Leipzig, Germany aut Lobsien Donald Department of Neuroradiology, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany aut Schwarz Johannes Department of Neurology, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany aut Sabri Osama Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103, Leipzig, Germany aut Journal of Neurology Springer-Verlag 258/1(2011-01-01), 19-26 0340-5354 258:1<19 2011 258 415 https://doi.org/10.1007/s00415-010-5666-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5666-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Strecker Karl Department of Neurology, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany aut NATIONALLICENCE 700 1- Wegner Florian Department of Neurology, Medical School Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Hesse Swen Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103, Leipzig, Germany aut NATIONALLICENCE 700 1- Becker Georg-Alexander Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103, Leipzig, Germany aut NATIONALLICENCE 700 1- Patt Marianne Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103, Leipzig, Germany aut NATIONALLICENCE 700 1- Meyer Philipp Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103, Leipzig, Germany aut NATIONALLICENCE 700 1- Lobsien Donald Department of Neuroradiology, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany aut NATIONALLICENCE 700 1- Schwarz Johannes Department of Neurology, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany aut NATIONALLICENCE 700 1- Sabri Osama Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, 04103, Leipzig, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/1(2011-01-01), 19-26 0340-5354 258:1<19 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer