caa a22 4500 445807091 CHVBK 20180317145159.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00415-010-5686-1 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5686-1 Sensory neuropathy in patients with cryoglobulin negative hepatitis-C infection [Elektronische Daten] [Min-Suk Yoon, Mark Obermann, Christina Dockweiler, Roland Assert, Ali Canbay, Sebastian Haag, Guido Gerken, Hans-Christoph Diener, Zaza Katsarava] There is growing evidence that hepatitis-C virus (HCV) infection might cause peripheral neuropathy. We aimed to investigate the prevalence, clinical and electrophysiological features of sensory neuropathy in patients with cryoglobulin negative HCV infection. We studied 46 consecutive cryoglobulin negative HCV positive patients (24 of them with and 22 without neuropathic symptoms, NS) and compared to 28 age and gender matched controls. In all patients and controls, clinical neuropathy symptom (NSS) and neuropathy deficit scores (NDS) were assessed and standard nerve conduction velocity (SNCV) and pain related-evoked potentials (PREP) were recorded. Both, SNCV and PREP were abnormal in 13 NS positive patients (13/46, 28%). Abnormal PREP but normal SNCV were found in 5 (5/46, 11%) NS positive and in 2 NS negative patients (2/46, 4%). PREP abnormalities correlated positive with both clinical neuropathy scores (NSS r=0.62; p<0.001; NDS r=0.57; p<0.001), but not with the duration of the disease, current viral load, or the virus subtype. PREP abnormalities were more frequent (16/33, 48.5%) in HCV patients treated with interferon than in therapy naïve patients (4/13, 30.8%); the difference was, however, not significant. In our present study (1) all virus subtypes are capable of inducing neuropathy, (2) no differences were found between interferon therapy and treatment naive patients, (3) the prevalence of peripheral sensory neuropathy including small sensory fibers (20/46, 43.5%) is higher than previously reported and (4) we found that detection of HCV associated neuropathy depends on the evaluation method. Springer-Verlag, 2010 HCV-infection nationallicence Small-fiber neuropathy nationallicence Pain-related evoked potentials nationallicence Prevalence nationallicence CNAS : Clinical neuropathy assessment score nationallicence HCV : Hepatitis-C virus nationallicence LEP : Laser evoked potentials nationallicence NDS : Neuropathy deficit score nationallicence NSS : Neuropathy symptom score nationallicence NS : Neuropathy symptoms nationallicence PREP : Pain related evoked potentials nationallicence SFN : Small-fiber neuropathy nationallicence SNCV : Standard nerve conduction velocity nationallicence Yoon Min-Suk Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut Obermann Mark Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut Dockweiler Christina Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut Assert Roland Laboratory Medicine, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut Canbay Ali Department of Gastroenterology and Hepatology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut Haag Sebastian Department of Gastroenterology and Hepatology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut Gerken Guido Department of Gastroenterology and Hepatology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut Diener Hans-Christoph Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut Katsarava Zaza Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut Journal of Neurology Springer-Verlag 258/1(2011-01-01), 80-88 0340-5354 258:1<80 2011 258 415 https://doi.org/10.1007/s00415-010-5686-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5686-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoon Min-Suk Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Obermann Mark Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Dockweiler Christina Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Assert Roland Laboratory Medicine, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Canbay Ali Department of Gastroenterology and Hepatology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Haag Sebastian Department of Gastroenterology and Hepatology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Gerken Guido Department of Gastroenterology and Hepatology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Diener Hans-Christoph Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut NATIONALLICENCE 700 1- Katsarava Zaza Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/1(2011-01-01), 80-88 0340-5354 258:1<80 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer