caa a22 4500 445807164 CHVBK 20180317145200.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00415-010-5684-3 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5684-3 Fatigue, sleepiness, and physical activity in patients with multiple sclerosis [Elektronische Daten] [S. Merkelbach, H. Schulz, H. Kölmel, G. Gora, J. Klingelhöfer, R. Dachsel, F. Hoffmann, U. Polzer] Fatigue is a frequent and disabling symptom in patients with multiple sclerosis (MS). The objective of the study was to compare fatigue and sleepiness in MS, and their relationship to physical activity. Eighty patients with MS rated the extent of experienced fatigue (Fatigue Severity Scale, FSS) and sleepiness (Epworth Sleepiness Scale, ESS). The relationship between the scales was analysed for the scales as a whole and for single items. The clinical status of the patients was measured with the Extended Disability Status Scale (EDSS). In addition, physical activity was recorded continuously for 1week by wrist actigraphy. The mean scores of fatigue and sleepiness were significantly correlated (FSS vs. ESS r=0.42). Single item analysis suggests that fatigue and sleepiness converge for situations that demand self-paced activation, while they differ for situations in which external cues contribute to the level of activation. While fatigue correlated significantly with age (r=0.40), disease severity (EDSS, r=0.38), and disease duration (r=0.25), this was not the case for sleepiness. Single patient analysis showed a larger scatter of sleepiness scores in fatigued patients (FSS>4) than in non-fatigued patients. Probably, there is a subgroup of MS patients with sleep disturbances that rate high on ESS and FSS. The amount of physical activity, which was measured actigraphically, decreased with disease severity (EDSS) while it did not correlate with fatigue or sleepiness. Springer-Verlag, 2010 Multiple sclerosis nationallicence Fatigue nationallicence Sleepiness nationallicence Sleep disturbance nationallicence Actigraphy nationallicence Merkelbach S. Heinrich-Braun-Klinikum Zwickau, 08056, Zwickau, Germany aut Schulz H. Helios-Klinikum Erfurt, Erfurt, Germany aut Kölmel H. Helios-Klinikum Erfurt, Erfurt, Germany aut Gora G. Fachkrankenhaus Hildburghausen, Hildburghausen, Germany aut Klingelhöfer J. Klinikum Chemnitz, Chemnitz, Germany aut Dachsel R. Klinikum Chemnitz, Chemnitz, Germany aut Hoffmann F. Krankenhaus Martha Maria, Halle/Saale, Germany aut Polzer U. Asklepios Fachklinikum Stadtroda, Stadtroda, Germany aut Journal of Neurology Springer-Verlag 258/1(2011-01-01), 74-79 0340-5354 258:1<74 2011 258 415 https://doi.org/10.1007/s00415-010-5684-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5684-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Merkelbach S. Heinrich-Braun-Klinikum Zwickau, 08056, Zwickau, Germany aut NATIONALLICENCE 700 1- Schulz H. Helios-Klinikum Erfurt, Erfurt, Germany aut NATIONALLICENCE 700 1- Kölmel H. Helios-Klinikum Erfurt, Erfurt, Germany aut NATIONALLICENCE 700 1- Gora G. Fachkrankenhaus Hildburghausen, Hildburghausen, Germany aut NATIONALLICENCE 700 1- Klingelhöfer J. Klinikum Chemnitz, Chemnitz, Germany aut NATIONALLICENCE 700 1- Dachsel R. Klinikum Chemnitz, Chemnitz, Germany aut NATIONALLICENCE 700 1- Hoffmann F. Krankenhaus Martha Maria, Halle/Saale, Germany aut NATIONALLICENCE 700 1- Polzer U. Asklepios Fachklinikum Stadtroda, Stadtroda, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/1(2011-01-01), 74-79 0340-5354 258:1<74 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer