caa a22 4500 445807202 CHVBK 20180317145200.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00415-010-5695-0 doi (NATIONALLICENCE)springer-10.1007/s00415-010-5695-0 Deep brain stimulation for camptocormia in dystonia and Parkinson's disease [Elektronische Daten] [Hans-Holger Capelle, Christoph Schrader, Christian Blahak, Wolfgang Fogel, Thomas Kinfe, Hansjoerg Baezner, Joachim Krauss] Camptocormia, or "bent spine syndrome”, may occur in various movement disorders such as primary dystonia or idiopathic Parkinson's disease (PD). Although deep brain stimulation (DBS) is an established treatment in refractory primary dystonia and advanced PD, few data are available on the effect of DBS on camptocormia comparing these two conditions. Seven patients (4 with dystonia, 3 with PD; mean age 60.3years at surgery, range 39-73years) with camptocormia were included in the study. Five patients underwent bilateral GPi DBS and two patients underwent bilateral STN DBS guided by CT-stereotactic surgery and microelectrode recording. Pre- and postoperative motor assessment included the BFM in the dystonia patients and the UPDRS in the PD patients. Severity of camptocormia was assessed by the BFM subscore for the trunk at the last available follow-up at a mean of 17.3months (range 9-36months). There were no surgical complications. In the four patients with dystonia there was a mean improvement of 53% in the BFM motor score (range 41-79%) and of 63% (range 50-67%) in the BFM subscore for the trunk at the last available follow-up (mean 14.3months, range 9-18months). In the three patients with camptocormia in PD who underwent bilateral STN DBS (2 patients) or pallidal DBS (1 patient), the PD symptoms improved markedly (mean improvement in the UPDRS motor subscore stimulation on/medication off 55%, range 49-61%), but there was no or only mild improvement of camptocormia in the two patients who underwent STN DBS, and only moderate improvement in the patient with GPi DBS at the last available follow-up (mean 21months, range 12-36months). GPi DBS is an effective treatment for camptocormia in dystonia. The response of camptocormia to chronic STN or GPi DBS in PD is more heterogenous. The latter may be due to a variety of causes and needs further clarification. Springer-Verlag, 2010 Camptocormia nationallicence Deep brain stimulation nationallicence Dystonia nationallicence Parkinson's disease nationallicence Capelle Hans-Holger Department of Neurosurgery, Medical School Hannover, MHH, Carl-Neuberg-Straße 1, 30652, Hannover, Germany aut Schrader Christoph Department of Neurology, Medical School Hannover, MHH, Hannover, Germany aut Blahak Christian Department of Neurology, University Hospital Mannheim, Mannheim, Germany aut Fogel Wolfgang Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany aut Kinfe Thomas Department of Neurosurgery, Medical School Hannover, MHH, Carl-Neuberg-Straße 1, 30652, Hannover, Germany aut Baezner Hansjoerg Department of Neurology, University Hospital Mannheim, Mannheim, Germany aut Krauss Joachim Department of Neurosurgery, Medical School Hannover, MHH, Carl-Neuberg-Straße 1, 30652, Hannover, Germany aut Journal of Neurology Springer-Verlag 258/1(2011-01-01), 96-103 0340-5354 258:1<96 2011 258 415 https://doi.org/10.1007/s00415-010-5695-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00415-010-5695-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Capelle Hans-Holger Department of Neurosurgery, Medical School Hannover, MHH, Carl-Neuberg-Straße 1, 30652, Hannover, Germany aut NATIONALLICENCE 700 1- Schrader Christoph Department of Neurology, Medical School Hannover, MHH, Hannover, Germany aut NATIONALLICENCE 700 1- Blahak Christian Department of Neurology, University Hospital Mannheim, Mannheim, Germany aut NATIONALLICENCE 700 1- Fogel Wolfgang Department of Neurology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany aut NATIONALLICENCE 700 1- Kinfe Thomas Department of Neurosurgery, Medical School Hannover, MHH, Carl-Neuberg-Straße 1, 30652, Hannover, Germany aut NATIONALLICENCE 700 1- Baezner Hansjoerg Department of Neurology, University Hospital Mannheim, Mannheim, Germany aut NATIONALLICENCE 700 1- Krauss Joachim Department of Neurosurgery, Medical School Hannover, MHH, Carl-Neuberg-Straße 1, 30652, Hannover, Germany aut NATIONALLICENCE 773 0- Journal of Neurology Springer-Verlag 258/1(2011-01-01), 96-103 0340-5354 258:1<96 2011 258 415 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer